Effect of Periodontal Treatment on Salivary Biomarkers
Not Applicable
- Conditions
- Chronic Periodontitis
- Interventions
- Procedure: periodontal treatment - scaling and root planning
- Registration Number
- NCT02159781
- Lead Sponsor
- The Baruch Padeh Medical Center, Poriya
- Brief Summary
The investigators plan to recruit 40 healthy patients referred to the unit of Periodontology, diagnosed with generalized moderate - severe chronic periodontitis.
treatment will include 4 - 6 sessions of scaling + root planning, oral hygiene instructions and motivation.
Whole saliva will be collected at intake and 8 - 14 weeks post periodontal treatment.
Saliva will be analyzed for trans locator protein. Study hypothesis: Periodontal treatment has an affect on saliva components.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- healthy patients
- moderate - sever chronic periodontitis
Exclusion Criteria
- systemic disease
- pregnancy
- subjects under the age of 18
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description periodontal treatmnent periodontal treatment - scaling and root planning -
- Primary Outcome Measures
Name Time Method Whole saliva & translocator protein (TSPO) Intake of patients than 8 - 12 weeks after periodontal treatment (scaling & root planning) Change in whole saliva \& translocator protein (TSPO) post periodontal treatment
- Secondary Outcome Measures
Name Time Method Periodontal measurements (periodontal pocket depth, bleeding on probing & clinical attachment level) Intake 8 - 12 weeks post periodontal treatment (scaling & root planning) periodontal probing depth, bleeding on probing and clinical attachment level.