The Effect of Periodontal Treatment on the Level of Free Radicals in the Saliva

• Conditions: Periodontitis

• Registration Number: NCT00969241
• Lead Sponsor: The Baruch Padeh Medical Center, Poriya

Brief Summary

This study will examine the relationship between free radicals in the saliva and periodontitis. 30 adults, 15 with periodontitis and 15 as a control group will give a sample of saliva before treatment and after treatment. The investigators will examine the free radicals in both groups.

Detailed Description

Periodontal disease is a chronic adult condition. Bacteria implicated in the etiology of this disease causes destruction of connective tissue and bone. As a result of stimulation by bacterial antigen PMN produces free radicals via respiratory burst as a part of host response to infection.

Free radicals can be defined as molecules or molecular fragments with an unpaired electron which imparts certain characteristics to the free radicals such as reactivity . Reactive free radicals are able to produce chemical modifications and to damage proteins, lipids, carbohydrates and nucleotides in the tissues.

Study Timeline

• Study Start: 2009-07
• Status Verified: 2009-08
• Study First Submitted: 2009-08-30
• Study First Submitted QC: 2009-08-31
• Study First Posted: 2009-09-01
• Primary Completion: 2010-12
• Last Update Submitted: 2010-12-22
• Last Update Posted: 2010-12-23

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• older than 18
• no medical problems

Exclusion Criteria

• medical problems

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

department of oral and maxillofacial surgery, Baruch Padeh Medical Center; 🇮🇱 Tieberia, Israel, Poria, Israel