The effect of quinine on food intake: oral sham feeding versus intragastric delivery

Completed

• Conditions: Obesity; overweight; 10003018

• Registration Number: NL-OMON48861
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 45

Inclusion Criteria

- Based on medical history and previous examination, no gastrointestinal
complaints can be defined.
- Age from 18 until 65 years. This study will include healthy adult subjects
(male and female).
- BMI from 18 until 25 kg/m2
- Bodyweight stable over at least the last 6 months (up until 5% weight change
allowed)

Exclusion Criteria

- History of severe cardiovascular, respiratory, urogenital, gastrointestinal/
hepatic, hematological/immunologic, HEENT (head, ears, eyes, nose, throat),
dermatological/connective tissue, musculoskeletal, metabolic/nutritional,
endocrine, neurological/psychiatric diseases, allergy, major surgery and/or
laboratory assessments which might limit participation in or completion of the
study protocol. The severity of the disease (major interference with the
execution of the experiment or potential influence on the study outcomes) will
be decided by the principal investigator.
- Use of medication that can influence study end-points (to be discussed by
medical doctor and principal investigator), including vitamin supplementation,
within 14 days prior to testing
- Administration of investigational drugs or participation in any scientific
intervention study which may interfere with this study (to be decided by the
principle investigator), in the 180 days prior to the study
- Major abdominal surgery interfering with gastrointestinal function
(uncomplicated appendectomy and hysterectomy allowed, and other surgery upon
judgement of medical doctor and principle investigator)
- Dieting (medically prescribed, vegetarian, diabetic, macrobiological,
biological dynamic)
- Unwillingness to eat lasagna bolognese meal
- Pregnancy, lactation
- Excessive alcohol consumption (>20 alcoholic consumptions per week)
- Smoking
- Non-tasters of bitter

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Food intake during an ad libitum pasta meal in the form of a pre made lasagna.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>VAS scores for satiety and GI symptoms.<br /><br>Heart rate variability (HRV)</p><br>