Effects of intragastric administration of quinine on gastric emptying, gut hormone release, blood glucose and appetite sensations, in healthy, lean volunteers.

Not Applicable

Completed

• Conditions: Obesity; Type 2 Diabetes; Healthy human gastrointestinal physiology; Diet and Nutrition - Obesity; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12618000813280
• Lead Sponsor: Christine Feinle-Bisset

Brief Summary

In healthy men, intragastric administration of quinine at the doses of 600mg and 275 mg alone stimulated insulin modestly. In response to the mixed-nutrient drink, both 600 mg and 275 mg doses reduced plasma glucose and stimulated insulin, the 275 mg dose significantly stimulated GLP-1, and 600 mg dose tended to stimulate GLP-1 and glucagon, compared with control. Quinine did not affect gastric emptying of the drink. In addition, there were no effects on appetite perceptions and gastrointestinal symptoms.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-05-11
• Study Completion: 2019-03-05
• Last Update Posted: 26 August 2019

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

A total of 15 healthy, lean (BMI 19-25 kg/m2) male subjects, aged between 18 - 55 years, will be included in each study part.

Exclusion Criteria

Significant gastrointestinal symptoms, disease or surgery;
Current gallbladder or pancreatic disease;
Cardiovascular or respiratory diseases; .
Any other illnesses as assessed by the investigator (including chronic illnesses not explicitly listed above);
Use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may affect energy metabolism, gastrointestinal function, body weight or appetite (eg domperidone and cisapride, anticholinergic drugs (eg atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, Astragalus, St Johns Wort etc.);
Individuals with low ferritin levels (less than 30 ng/mL), or who have donated blood in the 12 weeks prior to taking part in the study;
Lactose intolerance/other food allergy(ies);
Vegetarians;
Restrained eaters (score >12 on the three factor eating questionnaire);
Current intake of greater than 2 standard drinks on greater than 5 days per week;
Current smokers of cigarettes/cigars/marijuana;
Current intake of any illicit substance;
High performance athletes;
Inability to comprehend study protocol;
Unable to tolerate naso-gastric tube.

Study & Design

• Study Type: Interventional
• Study Design: Not specified