Clinical Study of Comorbidities of Attention Deficit Hyperactivity in Children and Adolescents.

• Conditions: Attention Deficit Hyperactivity Disorder
• Interventions: Diagnostic Test: IQ assessment using Wechsler intelligence scale for children third edition (WISC-III)

• Registration Number: NCT04946877
• Lead Sponsor: Assiut University

Brief Summary

Determine the frequency of psychiatric and neurological comorbidities in children and adolescence diagnosed with ADHD.

Detailed Description

ADHD is a common neurodevelopmental disorder characterized by hyperactivity, impulsivity, and inattention .ADHD is more often a complex disorder with a high rate of associated co-morbid conditions. Co-morbid conditions are prevalent among people with ADHD and increase its burden and complexity of management.Children with ADHD are at a higher risk than children without ADHD for developing other psychiatric disorders .Motor skill problems and Neurological soft signs are found in many neuropsychiatric conditions .NSS have been associated with inattention and behaviour difficulties for decades. Some researchers argue that these signs should be included in the diagnosis of ADHD .

Study Timeline

• Study First Submitted: 2021-06-23
• Study First Submitted QC: 2021-06-23
• Study First Posted: 2021-07-01
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-02
• Last Update Posted: 2022-02-03
• Study Start: 2022-03-01
• Primary Completion: 2022-08-01
• Study Completion: 2022-10-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Age: 6-17 years.
• Sex: both sexes will be included in the study.
• IQ≥70.

Exclusion Criteria

• Age: less than 6 years or more than 17 years.
• IQ<70.
• Patients with major neurological deficits, cerebral palsy and uncontrolled epilepsy.
• Patients with major psychiatric disorders e.g schizophrenia spectrum disorder.
• Patient who refusing to participate in the study or their caregiver refusing to give informed consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
control group	IQ assessment using Wechsler intelligence scale for children third edition (WISC-III)	100 normal children; they will be selected from neurology clinic complaining from minor neurological complaint e.g : headache, will match with the case group for age, sex and educational level.
case group	IQ assessment using Wechsler intelligence scale for children third edition (WISC-III)	100 ADHD patients; will be taken from outpatient clinic of child and adolescence psychiatry of Assiut university hospitals.

Primary Outcome Measures

Name	Time	Method
Determine psychiatric comorbidities in children and adolescents with ADHD using Mini international neuropsychiatric interview for children and adolescents (M.I.N.I. Kid).	baseline	Mini international neuropsychiatric interview for children and adolescents (M.I.N.I. Kid): is structured clinical diagnostic interview designed to assess the presence of current ICD-10 and DSM-IV psychiatric disorders in children and adolescents age 6-17 years

Secondary Outcome Measures

Name	Time	Method
determinate presence of soft neurological sign in children and adolescents with ADHD using Cambridge neurological inventory.	baseline	Neurological assessment using Cambridge neurological inventory: this is a clinical instrument constructed for standardized neurological assessment of psychiatric patients. It is useful for identifying neurological soft sign and other patterns of neurological impairments