Study of Attentional Disorders in Patients Suffering From Idiopathic Generalized Epilepsy.
- Conditions
- Idiopathic Generalized Epilepsy
- Interventions
- Other: Neuropsychological screening and high resolution EEG recording
- Registration Number
- NCT05530109
- Lead Sponsor
- University Hospital, Lille
- Brief Summary
Attentional disorders have been reported in neuropsychological studies evaluating patients suffering from generalized idiopathic epilepsy, but the data are disparate (in terms of test protocol). We aim to describe attentional and executive function disorder in IGE thanks to the Epitrack scale, validated in this specific population. Our secondary objective is to study the dynamic of cortical activity during an attentional task (the ANT), in order to describe the alteration of cortical networks in epileptic patients presenting with attentional disturbance.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 33
- Idiopathic generalized epilepsy followed-up during at least 2 years
- At least one antiepileptic drug medication
- No cognitive decline (MoCA score >26)
- Absence of concomitant pathology that could interfere with the purpose of the study.
- Be affiliated to the social security system
- Have signed an informed consent
- Pregnancy
- Not able to give consent (Article 1121-8 of the CSP) Vulnerable person Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP) Have a high probability of not respecting the protocol or of abandoning the study
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients with idiopathic generalised epilepsy Neuropsychological screening and high resolution EEG recording - healthy controls Neuropsychological screening and high resolution EEG recording age- and sex-matched healthy controls
- Primary Outcome Measures
Name Time Method Epitrack scale score At 1 month after inclusion EPITrack-Score shows the performance of attention and executive functions. Higher values indicate a better performance. scale from 9-49 (9 worst score - 49 best score)
- Secondary Outcome Measures
Name Time Method D2-R test score At 1 month after inclusion cortical source connectivity patterns.
STAI scale At 1 month after inclusion Anxiety-depressive symptoms score The State-Trait Anxiety Inventory (STAI) is a self-questionnaire, 20 questions, a score is calculated, ranging from 20 to 80, a high score indicating the presence of anxiety.
Raven's progressive matrice scores At 1 month after inclusion cortical source connectivity patterns.
Montreal Cognitive Assessment (MoCA) score At 1 month after inclusion Cognitive function was assessed by using MoCA score. Cognitive impairment was considered present when MoCA scores were \<26 .
quality of life using the Qolie-31 self questionnaire At 1 month after inclusion Quality Of Life In Epilepsy-Problems questionnaire (QOLIE31-P) questionnaire has been developed specifically to measure the quality of life of patients with epilepsy. The score ranges from 0 to 100 points. Higher scores reflect better quality of life; lower ones, worse quality of life.
BDI-II score At 1 month after inclusion Anxiety-depressive symptoms score Beck Depressive Inventory Questionnaire (BDI-II) (score), higher scores mean worse outcome, value minimum of 0 maximum 63
High resolution Electro Encephalo Gram functional connectivity markers at rest and during the ANT task At 1 month after inclusion limited number of reproducible resting activity patterns, brain networks involved in the absence of task performance
Trial Locations
- Locations (1)
Hopital Roger Salengro, CHU Lille
🇫🇷Lille, France