Effects of Attention Training Interventions on Depression
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 3
- 试验地点
- 2
- 主要终点
- changes in neural measures including "functional connectivity" functional magnetic resonance imaging (fMRI) collected during rest conditions
研究概览
简要总结
The purpose of this study is to study the effects of attention training interventions on symptoms and brain function in major depressive disorder.
详细描述
Attention training programs including mindfulness meditation-based interventions have been shown to be effective for treating depression. Currently the biological and psychological mechanisms of action of attention training for major depression disorder are unknown. The objective of the current study is to improve the investigator's understanding of the mechanisms of attention training interventions for depression.
Research participants will include approximately 165 individuals with major depressive disorder randomized to one of three types of attention training programs. Before and after intervention participants will complete a number of biological assessments including MRI, EEG, behavioral tasks, and questionnaires. The study will be completed across three visits: (1) a screening visit; (2) data collection session 1; and (3) data collection session 2.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
changes in neural measures including "functional connectivity" functional magnetic resonance imaging (fMRI) collected during rest conditions
时间窗: pre-treatment to post-treatment (approximately 3-4 weeks from intervention start date)
changes in behavioral task performance including related to cognitive processing (e.g., Flanker Task).
时间窗: pre-treatment to post-treatment (approximately 3-4 weeks from intervention start date)
changes in behavioral task performance including related to affective (e.g., Probabilistic Reward Task [PRT])
时间窗: pre-treatment to post-treatment (approximately 3-4 weeks from intervention start date)
changes in questionnaire measures including severity of depression (e.g., Beck Depression Inventory [BDI-II]: minimum/maximum values = 0/63, higher scores indicate worse outcome)
时间窗: pre-treatment to post-treatment (approximately 3-4 weeks from intervention start date)
次要结局
未报告次要终点
研究者
Matthew Sacchet
Assistant Neuroscientist
Mclean Hospital