Effects of Attention Training Interventions on Depression
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Depression
- Sponsor
- Mclean Hospital
- Enrollment
- 3
- Locations
- 1
- Primary Endpoint
- changes in neural measures including "functional connectivity" functional magnetic resonance imaging (fMRI) collected during rest conditions
- Status
- Terminated
- Last Updated
- 2 years ago
Overview
Brief Summary
The purpose of this study is to study the effects of attention training interventions on symptoms and brain function in major depressive disorder.
Detailed Description
Attention training programs including mindfulness meditation-based interventions have been shown to be effective for treating depression. Currently the biological and psychological mechanisms of action of attention training for major depression disorder are unknown. The objective of the current study is to improve the investigator's understanding of the mechanisms of attention training interventions for depression. Research participants will include approximately 165 individuals with major depressive disorder randomized to one of three types of attention training programs. Before and after intervention participants will complete a number of biological assessments including MRI, EEG, behavioral tasks, and questionnaires. The study will be completed across three visits: (1) a screening visit; (2) data collection session 1; and (3) data collection session 2.
Investigators
Matthew Sacchet
Assistant Neuroscientist
Mclean Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
changes in neural measures including "functional connectivity" functional magnetic resonance imaging (fMRI) collected during rest conditions
Time Frame: pre-treatment to post-treatment (approximately 3-4 weeks from intervention start date)
changes in behavioral task performance including related to cognitive processing (e.g., Flanker Task).
Time Frame: pre-treatment to post-treatment (approximately 3-4 weeks from intervention start date)
changes in behavioral task performance including related to affective (e.g., Probabilistic Reward Task [PRT])
Time Frame: pre-treatment to post-treatment (approximately 3-4 weeks from intervention start date)
changes in questionnaire measures including severity of depression (e.g., Beck Depression Inventory [BDI-II]: minimum/maximum values = 0/63, higher scores indicate worse outcome)
Time Frame: pre-treatment to post-treatment (approximately 3-4 weeks from intervention start date)