ISRCTN48560305已完成未知
Are early and late cardiovascular risk markers in women with polycystic ovary syndrome increased with concomitant non-alcoholic steatohepatitis and can this be modified with liraglutide?
Hull and East Yorkshire Hospitals NHS Trust (UK)0 个研究点目标入组 40 人开始时间: 2012年5月22日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Female
入选标准
- •Polycystic ovary syndrome (defined by the Rotterdam criteria) as 2 out of 3 of:
- •1. Oligo / anovulation
- •2. Clinical or biochemical evidence of hirsuitism, and/or
- •3. Polycystic ovaries on ultrasound and the exclusion of other disorders
- •4. Age 18-45 years
- •For normal controls:
- •1. Female, aged 18 - 45
- •2. Body madd index (BMI) 30 - 45
- •3. No current medical problems
排除标准
- •1. Ketoacidosis
- •2. Severe gastrointestinal disease
- •3. Hypothyroidism
- •4. Subjects taking regular medications associated with high risk of hepatotoxicity like isoniazid and methotrexate
- •5. Not using a reliable method of contraception
- •6. Patients not allowing disclosure to their GP's
- •7. History of pancreatitis
- •8. Heart Failure
- •9. Chronic renal failure (creatinine clearance less than 60 ml/min or plasma creatinine >150 umol/L)
- •10. Pregnancy or breastfeeding women
- •11. Liver function tests >300% reference range normal (eg ALT>90 u/mL)
- •12. Type 2 diabetes mellitus
- •13. Acute conditions with the potential to alter renal function such as: dehydration / severe infection / shock / intravascular administration of iodinated contrast
研究者
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