ISRCTN81902209
已完成
未知
Are early and late cardiovascular risk markers in women with polycystic ovary syndrome (PCOS) increased with concomitant non-alcoholic steatohepatitis (NASH) and can this be modified with exenatide?: An interventional open parallel single-centre trial
Hull and East Yorkshire Hospitals NHS Trust (UK)0 个研究点目标入组 20 人2009年5月13日
概览
- 阶段
- 未知
- 干预措施
- 未指定
- 疾病 / 适应症
- Polycystic ovary syndrome, non-alcoholic steatohepatitis
- 发起方
- Hull and East Yorkshire Hospitals NHS Trust (UK)
- 入组人数
- 20
- 状态
- 已完成
- 最后更新
- 6年前
概览
简要总结
2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/31001199 [added 26/04/2019]
研究者
入排标准
入选标准
- •1\. Polycystic ovary syndrome (defined by the Rotterdam criteria as 2 out of 3 of:
- •1\.1\. Oligo/anovulation
- •1\.2\. Clinical or biochemical evidence of hirsuitism, and/or
- •1\.3\. Polycystic ovaries on ultrasound
- •2\. Raised alanine aminotransferase (ALT)
- •3\. Female, age 16\-45 years
- •1\. Patients with confirmed NASH
- •3\. Age 16\-45 years
排除标准
- •1\. Ketoacidosis
- •2\. Severe gastrointestinal disease
- •3\. Type 2 diabetes
- •4\. Hypothyroidism
- •5\. Subjects taking regular prescribed medication
- •6\. Not using a reliable method on contraception (eg barrier/oral contraceptive pill)
- •7\. Patients not allowing disclosure to their GP's
- •8\. History of pancreatitis
- •9\. Chronic renal failure (creatinine clearance less than 60 ml/min or plasma creatinine \>150 umol/L)
- •10\. Pregnancy or breastfeeding women
结局指标
主要结局
未指定
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Are early and late cardiovascular risk markers in women with Polycystic Ovary Syndrome increased with concomitant Nonalcoholic Steatohepatitis and can this be modified with Exenatide? - CV risk in PCOS and NASHEUCTR2008-006928-55-GBHull and East Yorkshire NHS Trust
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