A Prospective Study for Pleural Lavage Cytology in Patients With Esophageal Cancer
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 385
- 试验地点
- 11
- 主要终点
- number of patients who had positive pleural lavage cytology
研究概览
简要总结
Disease recurrence and metastasis are common after curative treatment for patients with esophageal cancer. Thus, it is important to identify the risk factors to predict disease recurrence and metastasis. Pleural lavage cytology (PLC) is reported to be associated with disease recurrence and patient survival in lung cancer, but the value is unclear in esophageal cancer. The aim of this study is to evaluate the value of PLC in esophageal cancer patient in terms of frequencies, association with patient survival, and efficacy of postoperative treatment.
详细描述
Pleural lavage cytology will be performed before esophageal resection, and after resection, respectively. Frequency of positive pleural lavage cytology will be determined, and the value of pleural lavage cytology for patients with resectable esophageal cancer will be studied.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •esophageal cancer with histological confirmation before treatment.
- •resectable esophageal cancer with clinical T1-4a/N0-3/M0 staging
- •potential R0 resection
- •no history of other malignancies
排除标准
- •severe major organ dysfunction (American society of anesthesiologisits score >3 )
- •patients underwent ESD or EMR
- •pleural lavage is unavailable due to adhesions
结局指标
主要结局
number of patients who had positive pleural lavage cytology
时间窗: July 2022 to July 2023
Frequency of positive pleural lavage cytology in resectable esophageal squamous cell carcinoma
次要结局
- Time period from date of surgery to the date of death(July 2022 to July 2026)
研究者
Haiquan Chen
Fudan University Shanghai Cancer Center
Fudan University