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临床试验/NCT05138302
NCT05138302Unknown不适用

A Prospective Multicenter Clinical Study of BRCA and DNA Damage Repair Genes in Blood Samples of Chinese Pancreatic Cancer Patients

RenJi Hospital1 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2021年4月19日最近更新:
适应症

试验速览

阶段
不适用
入组人数
1,000
试验地点
1
主要终点
OS

研究概览

简要总结

This study aims to know the status of BRCA and DDR genes in PDAC patients in China. Peripheral venous blood samples of the patients will be collected for next-generation sequencing of BRCA and DNA damage repair related genes. At the same time, it is necessary to record clinical information such as age, gender, tumor pathological type, tumor stage and grade, whether surgery is performed, the size of postoperative residual lesions, and treatment methods. Prognostic indicators include the association of factors such as PFS, ORR, and DCR are also recorded.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients diagnosed with pancreatic cancer
  • PS score ≤ 2
  • no severe heart, cerebrovascular disease, severe coagulation dysfunction or severe mental disorder

排除标准

  • PS score > 2
  • with severe heart, cerebrovascular disease, severe coagulation dysfunction or severe mental disorder

结局指标

主要结局

OS

时间窗: 2years

Overall survival

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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