The effect of modulating hepatic glycogen content on hepatic fat oxidatio
- Conditions
- fatty liverNon-alcoholic fatty liver (NAFL)1001965410013317
- Registration Number
- NL-OMON45924
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 34
- Signed informed consent
- Caucasian (people will be excluded when having a *50% racial African/Asian background)
- Male or postmenopausal female
- Aged 45-75 years at start of the study
- Body mass index (BMI) 27 * 38 kg/m2
- Stable dietary habits (no weight loss or gain >3kg in the past 3 months)
- Sedentary lifestyle (not more than 2 hours of sports per week)
- Liver fat *5% as determined by 1H-MRS
- Type 2 diabetes
- Active diseases (cardiovascular, diabetes, liver, kidney, cancer or other)
- Contra-indication for MRI
- Alcohol consumption of >2 servings per day
- Regular smoking (>5 cigarettes per day)
- No use of medication interfering with investigated study parameters (as determined by responsible physician)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
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