Effect of ferrous sulfate on attention-deficit/hyperactivity disorder symptoms in childre

Phase 2

Conditions: Attention deficit/hyperactivity disorder.
A group of disorders characterized by an early onset (usually in the first five years of life), lack of persistence in activities that require cognitive involvement, and a tendency to move from one activity to another without completing any one, together

Registration Number: IRCT201212012269N2

Lead Sponsor: Vice chancellor for research, Guilan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 50

Inclusion Criteria

1. Children with attention-deficit/hyperactivity disorder based on DSM-IV TR and under Methylphenidate treatment
2. Lack of anemia (Hemoglobin lower than 11 g/dl)
3. Blood ferritin level lower than 30 ng/ml

Exclusion criteria:
1. Comorbidity of attention-deficit/hyperactivity disorder with other psychiatric disorders
2. Serious and chronic medical disorders (such as malnutrition)
3. Mental retardation
4. Recent inflammation or infection
5. Use of psychopharmacological medications
6. Iron supplementation consumption during recent 3 months, or contraindication for use it.
7.Severe fever (because of pseudo increase in ferritin level)
8.Hypothyroidism (because of pseudo decrease in ferritin level)

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ferritin. Timepoint: Before intervention, 3 months later. Method of measurement: Blood sampling, monobind kit, ELISA method.;Hemoglobin. Timepoint: Before intervention, 3 months later. Method of measurement: Blood sampling, immunometric method with autoanalyzer.;TIBC. Timepoint: Before intervention, 3 months later. Method of measurement: Blood sampling, Ziest Chem kit, fluorometry method.;Iron. Timepoint: Before intervention, 3 months later. Method of measurement: Blood sampling, Ziest Chem kit, fluorometry method.

Secondary Outcome Measures

Name	Time	Method
Attention Deficit Hyperactivity Disorder (ADHD) index. Timepoint: First, Sixth, and twelfth weeks. Method of measurement: Conners' Parent Rating Scale (CPRS).