Effect of Whole-body Electromyostimulation Combined With Individualized Nutritional Support on Patients With Hematological Malignancies
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Hematologic Diseases
- Sponsor
- University of Erlangen-Nürnberg Medical School
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Skeletal muscle mass
- Last Updated
- 7 years ago
Overview
Brief Summary
This study evaluates the effects of a whole-body electromyostimulation (WB-EMS) training combined with individualized nutritional support on skeletal muscle mass, body composition, muscle strength/function, quality of life, fatigue, pain and gastrointestinal symptoms in patients with hematological malignancies 4-6 weeks before and 4-6 weeks after undergoing stem cell Transplantation. Within this context, this study also investigates the effect of the nutrition and exercise intervention on the period of hospitalization, period of White blood cell recovery and frequency and severity of complications (mucositis, Graft-versus-Host-Disease, infections) after stem cell Transplantation as consequences of the therapeutic immune Suppression.
Investigators
Eligibility Criteria
Inclusion Criteria
- •adult patients diagnosed with hematological malignancies with an indication for stem cell Transplantation
- •Interval until Transplantation: 6 weeks
- •ECOG Status 0-2
Exclusion Criteria
- •patients with serious osteolytic lesions and increased risk of fall
- •simultaneous participation in other nutritional or exercise intervention Trials or in the past 6 months
- •acute cardiovascular events
- •use of anabolic medications
- •severe neurological diseases
- •skin lesions in the area of electrodes
- •energy active metals in body
- •acute vein thrombosis
- •rheumatic diseases
- •pregnant and nursing women
Outcomes
Primary Outcomes
Skeletal muscle mass
Time Frame: 12 weeks
Skeletal muscle mass assessed by bioelectrical impedance analysis (in kg)
Secondary Outcomes
- Depression/Anxiety(12 weeks)
- Inflammatory blood markers(12 weeks)
- Physical function - Isometric muscle strength(12 weeks)
- Cardiorespiratory Fitness(12 weeks)
- Patient-reported Quality of Life (QoL)(12 weeks)
- Patient-reported Fatigue(12 weeks)