Comparing the efficacy of Buprenorphine and Clonidine when combined with Ropivacaine in spinal anesthesia of leg surgeries.

Phase 1

Completed

• Conditions: Disorders of bone density and structure,

• Registration Number: CTRI/2020/02/023197
• Lead Sponsor: Vasanth D

Brief Summary

This is randomised controlled trial to compare the plain ropivacaine, Buprenorphine with ropivacaine and Clonidine with ropivacaine given intrathecally for patient undergoing lower limb orthopaedic surgeries,among 75 patients are divided in 3 groups over a period of 18 months.The primary objective is to compare the duration of analgesia between 3 groups.The secondary objectives are onset of sensory blockade, haemodynamic changes during intra operative period and quality of analgesia post operatively.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-10-02
• Study Completion: 2021-10-30
• Last Update Posted: 2022-05-05

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

Patients undergoing elective upper limb surgeries American Society of Anaesthesiologist I or II.

Exclusion Criteria

• Patient refusal.
• Allergic to opioids/ local anaesthetics.
• Height < 140 cm , BMI > 30 Patient with recent history of CVA.
• Coagulation disorder.
• Severe CVS abnormalities.
• Poorly controlled hypertension.
• Poorly controlled Diabetes mellitus.
• Emergency orthopaedic surgery.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare duration of analgesia of Ropivacaine, Buprenorphine with ropivacaine, Clonidine with ropivacaine given intrathecally in terms of first	Post operative period
rescue analgesia requirement	Post operative period

Secondary Outcome Measures

Name	Time	Method
Time taken for onset of sensory and motor blockade.	Intra operative haemodynamic changes.

Trial Locations

Locations (1)

Shri sathya sai medical college and research institute; 🇮🇳 Kancheepuram, TAMIL NADU, India

Shri sathya sai medical college and research institute

🇮🇳Kancheepuram, TAMIL NADU, India

Vasanth D

Principal investigator

8220320737

vasanth_1686@yahoo.com