Efficacy and safety of oral spironolactone combined with 3% topical minoxidil for the treatment of female pattern hair loss in premenopausal women: A randomized, double- blind, placebo-controlled study.

Srinakharinwirot university0 个研究点目标入组 43 人开始时间: 2022年6月13日最近更新: 2024年8月19日

适应症

试验速览

阶段: 2 期
状态: 已完成
发起方: Srinakharinwirot university
入组人数: 43

研究概览入排标准研究者记录与标识符相似试验

研究概览

简要总结

Spironolactone is an alternative for female pattern hair loss in reproductive-age women when standard treatments fail. Taking 100 mg daily with 3% Minoxidil tends to be more effective than Minoxidil alone, but may cause mild menstrual irregularities. - Taking 100 mg of Spironolactone daily with Minoxidil enhances female pattern hair loss treatment efficacy.

研究设计

研究类型: Interventional

入排标准

年龄范围: 18 Years 至 45 Years（—）
性别: Female

入选标准

•1. The patient who is diagnosed with female pattern hair loss (Ludwig grade 1-2)
•2. Premenopause
•3. Ability to see a doctor by appointment
•4. Agree to join in research and sign a consent
•5. Get COVID-19 vaccination at least 2 dose

排除标准

•1. History of chronic renal disease, hepatic disease, cardiovascular disease, Hypertension, Diabetes Mellitus, cancer and Addison's disease.
•2. Family history of breast cancer in first degree relatives.
•3. Allergic to spironolactone or minoxidil.
•4. The patients who take drugs that caused interaction with spironolactone, for example, ACE inhibitors, angiotensin II antagonists, heparin, low molecular weight heparin, lithium, NSAIDs, digoxin, chloestyramine, narcotic drug, corticosteroids.
•5. During pregnancy or breast feeding periods.
•6. The patients who don't get contraception.
•7. The patients who has at least 1 abnormal serum level of BUN > 20.1 mg/dL, creatinine > 1.17, sodium < 135 mmol/L, potassium > 5.1 mmol/L
•8. The patients who had history of using drugs that affect to hair regrowth within 6 months before participating in research study, for example, finasteride, dutasteride, flutamide, cyproterone acetate, spironolactone, minoxidil, cimetidine, diazoxide, cyclosporine, ketoconazole,corticosteroids, chemotherapeutic agents, anticonvulsant ,vasodilators
•9. The patients who had history of using topical drugs that affect to hair regrowth within 3 months,
•for example, minoxidil ,finasteride.
•10. The patients who had history of using shampoo or hair serum that affects to hair regrowth within 1 months
•11. The patients who had history of other treatments for hair loss within 3 months before participating in research study, for example, low-level laser/light therapy ,platelet-rich plasma.
•12. The patients who had history of hair transplantation before participating in research study.
•13. The patients who has underlying diseases that can cause hair loss, for example, hypo/hyperthyroidism, anemia, malabsorbtion syndrome ,trichotillomania
•14. History of diet control or abnormal eating disorder.
•15. History of abnormal scalp disease such as seborrheic dermatitis, Tinea capitis

研究者

发起方

Srinakharinwirot university

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