Protein turnover in the osteoarthritic knee; the impact of preoperative protein intake.

Recruiting

• Conditions: Knee osteoarthritis; Osteoarthritis of the knee; 10037008; 10023213

• Registration Number: NL-OMON54781
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

- Written informed consent
- Male and female patients scheduled for total knee arthroplasty
- BMI between 18.5-35 kg/m2
- Age >18 years
- Mentally competent, as judged by the treating physician
- Functioning gastrointestinal tract, eligible for oral protein supplementation

Exclusion Criteria

- Corticosteroid injections less than 3 months prior to participation
- Any medications know to affect protein metabolism (i.e. systemic
corticosteroids or prescription strength acne medications)
- Lactose intolerance
- Insulineafhankelijke diabetes mellitus
- Alcohol abuse
- Rheumatoid arthritis
- Peripheral artery disease Fontaine III or IV
- COPD GOLD III or IV
- Pheynylketonuria
- Surgical intervention to the knee in the past four weeks
- Total parenteral nutrition at day of surgery
- Neoadjuvant chemotherapy or radiotherapy
- GFR <20 mL/min/1.73 m2
- Osteoarthritis of the knee secondary to septic arthritis, osteonecrosis,
fracture, OD, or malignant processes
- Collagen disorders, e.g. Marfan and Ehler-Danlos
- Any other medical condition that may interfere with the safety of the
subjects or the outcome parameters, in the investigators judgement
- Investigator*s uncertainty about the willingness or ability of the subject to
comply with the protocol instructions
- Participation in any other studies involving investigational or marketed
products concomitantly or within two weeks prior to entry into the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameters include protein synthesis rates and enrichments of<br /><br>Hoffa*s fat pad, synovium, tendon, bone, muscle, ligament, menisci, and<br /><br>cartilage.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters include whole-body protein synthesis, breakdown,<br /><br>oxidation, and net balance. </p><br>