molecular MRI in knee osteoarthritis: application and validation of biochemically sensitive MRI-sequences

• Conditions: M17.1; Other primary gonarthrosis

• Registration Number: DRKS00000729
• Lead Sponsor: niversitätsklinikum Düsseldorf

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-02-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patients, who are diagnosed with a knee osteoarthritis and are planned to receive a total knee replacement.

Exclusion Criteria

no written consent after information; technical implants, metal fragments; non-removable decoration; claustrophobia; cannot ly down for a long time including lung dysfunction or reflux; pregnancy; breast feeding mother; allergic reaction to contrast agent; allergic asthma; renal dysfunction - to be demonstrated in a creatinin-value within normal range; liver dysfunction; acute or chronic infections, epilepsia, brain disease, tumors.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hypothesis: cartilage degeneration can be demonstrated with the aid of molecular cartilage MRI. Changes can be reproduced histologically<br>

Secondary Outcome Measures

Name	Time	Method
no secondary outcome