Diagnostic imaging of synovitis in knee osteoarthritis (DISKO)
Recruiting
- Conditions
- Synovitis10013361mucosal inflammation
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
- Age * 18 years;
- Clinical signs of knee OA: knee pain (numeric rating scale > 3);
- Radiographic signs of knee osteoarthritis (radiographic Kellgren and Lawrence grade *1 );
- Signs of synovitis (i.e. joint effusion) on physical examination of the knee;
Exclusion Criteria
- Subjects with a typical (e.g. metallic foreign bodies, etc.) contra-indication for an MRI exam;
- Renal insufficiency, checked with blood sample test (GFR < 60 ml/min/1,73 m²);
- Known allergy to contrast agents;
- Known pulmonary hypertension
- Woman who are pregnant or lactating
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Correlations between synovitis visualized on non-contrast DESS and: 1) CE-MRI;<br /><br>2) Tissue markers of synovial inflammation and specific inflammatory subtypes;<br /><br>3) Other OA features on MRI; 4) knee OA symptoms and 5) (CE)US findings<br /><br>related to synovitis.</p><br>
- Secondary Outcome Measures
Name Time Method <p>1. Synovial Ttissue and synovial fluid markers of synovial inflammation and<br /><br>specific inflammatory subtypes;<br /><br>2. Other OA features on MRI, particularly compositional and morphological<br /><br>change in cartilage and meniscus, altered blood perfusion in synovium and<br /><br>subchondral bone, and osteophyte formation;<br /><br>3. Knee OA symptoms, especially those related to synovitis (i.e. joint<br /><br>stiffness, self-reported feeling of swelling, pain patterns (constant versus<br /><br>intermittent pain)), recorded with validated standardized questionnaires (like<br /><br>ICOAP, KOOS, VAS and WOMAC).<br /><br>4. US findings related to synovitis</p><br>