Association Between EEG Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation

Not yet recruiting

• Conditions: Endotracheal Intubation; Surgical Incision; Electroencephalogram; Abdominal Surgery

• Registration Number: NCT06228729
• Lead Sponsor: Seoul National University Hospital

Brief Summary

This study aims to prospectively evaluate the relationship between changes in EEG and hormonal responses induced by endotracheal intubation and surgical incision following general anesthesia.

Detailed Description

This study aims to investigate the relationship between changes in EEG patterns and stress hormone levels in patients undergoing open abdominal surgery under general anesthesia when subjected to endotracheal intubation and surgical incision stimuli.

Hormone measurements (cortisol, ACTH) are taken at four time points: before endotracheal intubation (T1), one minute after intubation (T2), and one minute after surgical incision (T3). The investigators evaluate the correlation between hormone levels (cortisol, ACTH) and EEG band power changes (alpha, beta, delta) before and after endotracheal intubation and surgical incision.

Study Timeline

• Study First Submitted: 2024-01-18
• Study First Submitted QC: 2024-01-18
• Study First Posted: 2024-01-29
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-12
• Last Update Posted: 2024-06-14
• Study Start: 2024-07-01
• Primary Completion: 2024-09-01
• Study Completion: 2024-12-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

• 1. Patients scheduled to undergo open abdominal surgery under general anesthesia with endotracheal intubation.
• 2. Patients requiring invasive blood pressure monitoring during surgery

Exclusion Criteria

• 1. Patients transferred to the intensive care unit after surgery
• 2. Surgery duration of less than one hour
• 3. Patients with neurological underlying conditions
• 4. Patients on chronic use of psychotropic medications and opioid drugs
• 5. Emergency surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Association between band power changes in EEG and hormone respones caused by endotracheal intubation	from the start of anesthesia induction to one minute after endotracheal intubation

Secondary Outcome Measures

Name	Time	Method
Association between band power changes in EEG and hormone respones caused by surgical incision	from the start of anesthesia induction to one minute after surgical incision