Role of Cord Blood Hormones and Epinephrine in the Development of Transient Tachypnea of the Newborn

Completed

• Conditions: Wet Lung

• Registration Number: NCT01149928
• Lead Sponsor: Ankara University

Brief Summary

In this prospective, cross-sectional study, the aim was to investigate the possible role of cord stress hormones; adrenocorticotropic hormone (ACTH), cortisol, epinephrine, sT3, sT4, and thyroid-stimulating hormone (TSH) in the development of Transient Tachypnea of the Newborn (TTN), via their modulatory effect on epithelial sodium channels and Na-K-ATPase.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-09
• Primary Completion: 2009-08
• Status Verified: 2009-10
• Study Completion: 2009-10
• Study First Submitted: 2010-06-21
• Study First Submitted QC: 2010-06-23
• Last Update Submitted: 2010-06-23
• Study First Posted: 2010-06-24
• Last Update Posted: 2010-06-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Gestation age > 34 weeks
• C/S delivered infants
• Parental consent form signed

Exclusion Criteria

• Gestation age < 34 weeks
• Maternal conditions that compromised fetal well-being (hypertensive disorder, diabetes, chorioamnionitis)
• Intrauterine growth retardation
• Congenital malformations
• Absence of parental consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Stress response at birth, as demonstrated by cord cortisol, adrenocorticotropic hormone, epinephrine, fT3, fT4, and thyroid-stimulating hormone in late preterm and term neonates developing transient tachypnea of the newborn.	postnatal first 24 hours	At birth cord blood samples and perinatal data were collected from ceseraen deliveries of late preterm and term infants. Cord stress hormones of the infants with the diagnosis of TTN and gestational age matched controls were analyzed.