The Effects of Pain and Pain Relief on Peripheral Nerve Excitability

University of Aarhus1 site in 1 country30 target enrollmentDecember 20, 2023

ConditionsAnalgesia

Overview

Phase: N/A
Intervention: Not specified
Conditions: Analgesia
Sponsor: University of Aarhus
Enrollment: 30
Locations: 1
Primary Endpoint: C-fiber excitability
Status: Recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study will assess changes in nerve excitability of C-fibers, and changes in sympathetic or parasympathetic tone, when the subject experiences pain and pain relief.

The investigators will continuously measure blood pressure, heart rate, respiration rate, gastric motility, sympathetic skin response and C-fiber excitability while using thermal stimuli before and after an analgesic.

Registry

clinicaltrials.gov

Start Date

December 20, 2023

End Date

April 30, 2024

Last Updated

2 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University of Aarhus

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Healthy Participants able to give informed consent.

Exclusion Criteria

•Chronic pain conditions
•Neurological or Psychiatric disease
•Other major diseases
•Pain medication within the last 24 hours

Outcomes

Primary Outcomes

C-fiber excitability

Time Frame: Through study completion, an average of 6 months

Changes in C-fiber excitability measured in latency changes after electrical stimulation with a paired pulse protocol compared to an unpaired electrical stimulus.

Secondary Outcomes

Action potential duration (ms)(Through study completion, an average of 6 months)
Heart-rate variability (ms)(Through study completion, an average of 6 months)
Blood pressure variability (mmHg)(Through study completion, an average of 6 months)
Action potential amplitude (V)(Through study completion, an average of 6 months)
Sympathetic Skin Response (V)(Through study completion, an average of 6 months)