Pro-Nociceptive and Anti-Nociceptive Mechanisms Across an Episode of Recurrent Low Back Pain
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Recurrent Low Back Pain
- Sponsor
- Aalborg University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Temporal Summation of Pain
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This study evaluates psychophysical measures of pain inhibition and facilitation, along with cortical responses to different sensory stimuli, in patients with recurrent low back pain and matched healthy individuals.
Detailed Description
Pain inhibitory and facilitatory mechanisms have been suggested to play a role in the development of persistent low back pain; however, there is still debate on when changes in these mechanisms occur. Similarly, evoked cortical responses can reflect neuroplastic changes in pain processing regions, which are also thought to play a role in the transition to persistent pain, but there is also debate on when these neuroplastic changes develop relative to low back pain. Therefore, this study will use patients with an intermediary clinical pain state, recurrent low back pain, and matched healthy control participants, to investigate within and between subject differences in pain inhibitory, facilitatory and neuroplastic mechanisms.
Investigators
Megan McPhee
PhD Fellow
Aalborg University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Temporal Summation of Pain
Time Frame: Day 0 vs. Day 28
Pain rating (VAS) change over a series of 10 repeated mechanical stimuli
Conditioned Pain Modulation
Time Frame: Day 0 vs. Day 28
Pressure pain threshold (kPa) as test stimulus before compared to during a pressure conditioning stimulus on the lower leg
Secondary Outcomes
- Pressure Pain Thresholds(Day 0 vs. Day 28)
- Thermal Pain Thresholds(Day 0 vs. Day 28)
- Proprioceptive Weighting(Day 0 vs. Day 28)
- Two Point Discrimination(Day 0 vs. Day 28)
- Sensory Evoked Potentials(Day 0 vs. Day 28)