High Fresh Gas Flow After Intubation

Not Applicable

Completed

• Conditions: Atelectasis
• Interventions: Procedure: Control group, conventional ventilatory settings; Procedure: High fresh gas flow, high minute ventilation

• Registration Number: NCT02216006
• Lead Sponsor: Region Västmanland

Brief Summary

Atelectasis is common during and after general anesthesia. Atelectasis develops early if preoxygenation with 100% oxygen is used and continuously used during induction until endotracheal intubation. The investigators hypothesize that a rapid anti-preoxygenation maneuver immediately after confirming a successful intubation, reduces the area of atelectasis as investigated by computed tomography compared to a standard procedure.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-08-01
• Study First Submitted QC: 2014-08-12
• Study First Posted: 2014-08-13
• Study Start: 2014-09
• Status Verified: 2015-05
• Primary Completion: 2015-05
• Study Completion: 2015-05
• Last Update Submitted: 2015-05-12
• Last Update Posted: 2015-05-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Healthy patients, American Society of Anesthesiology (ASA) I-II
• Patients scheduled for orthopaedic day case surgery in general anaesthesia

Exclusion Criteria

• ASA class III or higher
• Body Mass Index (BMI) 30 or higher
• Arterial oxygen saturation (SpO2) <94% breathing air
• Chronic Obstructive Pulmonary Disease (COPD)
• Ischemic heart disease
• Haemoglobin <100g/L
• Known or anticipated difficult airway and/or intubation
• Active smokers and ex-smokers with a history of more than 6 pack years
• Need for interscalene or supraclavicular regional anaesthesia with risk of phrenic nerve paralysis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group, conventional ventilatory settings	Control group, conventional ventilatory settings	Handling of the airway during induction and intubation is performed in a conventional manner. Initial ventilatory settings are also done in a conventional manner.
High fresh gas flow, high minute ventilation	High fresh gas flow, high minute ventilation	Handling of the airway during induction and intubation is performed in a conventional manner. Immediately after confirming a successful intubation the effect of preoxygenation is eliminated with an anti-preoxygenation maneuver.

Primary Outcome Measures

Name	Time	Method
Atelectasis	Within 1-2 hours, just before emergence from anesthesia	The area of atelectasis in the lungs is assessed by computed tomography (CT) 10 mm above the dome of the right diaphragm and expressed in cm2 and as % of the total lung area in the particular scan.

Secondary Outcome Measures

Name	Time	Method
Arterial blood gases	Within 2-3 hours perioperatively

Trial Locations

Locations (1)

Landstinget Västmanland; 🇸🇪 Köping, Västmanland, Sweden