High-flow Nasal Oxygenation During Preoxygenation and Atelectasis

Not Applicable

Recruiting

• Conditions: Pulmonary Atelectasis; Anesthesia, General
• Interventions: Other: high-flow nasal oxygen; Other: facemask

• Registration Number: NCT06205212
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Atelectasis after induction of general anesthesia is common even in healthy patients and is clinically problematic, especially in obese patients. We aim to investigate whether preoxygenation with high-flow nasal oxygen during anesthesia induction reduces atelectasis in obese patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-09
• Study First Submitted: 2023-09-19
• Study Start: 2023-10-10
• Study First Submitted QC: 2024-01-03
• Last Update Submitted: 2024-01-03
• Study First Posted: 2024-01-12
• Last Update Posted: 2024-01-12
• Primary Completion: 2024-10-10
• Study Completion: 2024-10-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 92

Inclusion Criteria

• Adults patients undergoinig surgery under general anesthesia with a BMI of 30 kg/m2 or greater who have given informed consent

Exclusion Criteria

• surgery time less than 2 hours
• Nasotracheal intubation
• Severe cardiac or respiratory disease
• History of difficult airway
• History of a surgery or anatomical anomaly in the head and neck
• History of Inability to breathe through nose
• Gastric reflux disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
high-flow nasal oxygen	high-flow nasal oxygen	preoxygenation using high-flow nasal cannula oxygen
facemask	facemask	preoxygenation using a conventional facemask

Primary Outcome Measures

Name	Time	Method
Lung ultrasound score	Immediately after anesthesia induction	modified LUSS

Secondary Outcome Measures

Name	Time	Method
Incidence of atelectasis	Immediately after anesthesia induction
length of hospital stay	up to 1 year
Patient Satisfaction Score	During preoxygenation
Lung ultrasound score	In the PACU after surgery
PaO2 to FiO2 ratio and PaCO2	Immediately after anesthesia induction
Hemodynamic variables	During anesthesia induction	Blood pressure, heart rate, pulse oximetry
Incidence of Spo2 less than 95%	during 48 hours postoperatively
Maximum body temperature	during hospitalization up to 1 week
Incidence of postoperative pulmonary complications	during hospitalization up to 1 week

Trial Locations

Locations (1)

SMG - SNU Boramae Medical Center; 🇰🇷 Seoul, Korea, Republic of