Effects of Treatment With High Flow Nasal Cannulas on Respiratory Pattern and Work of Breathing Among Healthy Subjects
- Conditions
- Respiratory Failure
- Interventions
- Device: High flow nasal cannulasDevice: Conventional flow via nasal prongs
- Registration Number
- NCT02495675
- Lead Sponsor
- Laval University
- Brief Summary
This study evaluates the work of breathing among healthy subjects under various conditions of treatment with high flow nasal cannulas. Ten subjects will be included. The design of this study is a cross over of five treatment periods with different flow settings.
- Detailed Description
High flow oxygen therapy (HFOT) is a promising technique increasingly used in the management of acute respiratory failure. In hospitalised hypoxemic patients, recent clinical evidence showed that HFOT can reduce endotracheal intubation and reduce mortality. Physiologically, the HFOT causes a decrease in respiratory rate and minute-ventilation and may be associated with a decrease in carbone dioxyde arterial pressure. It is possible that these effects are associated with decreased work of breathing, which could explain some of the benefits in terms of comfort and efficiency.
The objective of this research is to evaluate the impact of a wash-out of anatomical dead space by high flow nasal cannulas on respiratory parameters and on the work of breathing among healthy subjects. The investigators will evaluate the baseline status in room air, and then compare it with four different levels of flow. The primary endpoint will be the work of breathing.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 10
- Healthy subjects
- Written and informed consent
- Pregnant or breastfeeding women;
- Subject enrolled in another study excluding co-enrolment;
- Cardio-vascular or respiratory disease;
- History of ear nose and throat disease (i.e. surgery, epistaxis, trauma), eso-gastric disease (i.e. esophageal varices, digestive haemorrhage), rheumatologic or neurologic disease possibly interfering with the design of the study;
- Subject feeling nauseous or under recent fed condition (<1h).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description High flow nasal cannulas 20 L/min High flow nasal cannulas Subjects will be breathing with high flow nasal cannulas delivering 20 L/min with an inspired fraction of oxygen of 0.21. Conventional flow via nasal prongs Conventional flow via nasal prongs Subjects will be breathing with nasal prongs delivering 5 L/min of air (inspired fraction of oxygen: 0.21) High flow nasal cannulas 60 L/min High flow nasal cannulas Subjects will be breathing with high flow nasal cannulas delivering 60 L/min with an inspired fraction of oxygen of 0.21. High flow nasal cannulas 40 L/min High flow nasal cannulas Subjects will be breathing with high flow nasal cannulas delivering 40 L/min with an inspired fraction of oxygen of 0.21.
- Primary Outcome Measures
Name Time Method Work of breathing 10 minutes Work of breathing at the end of each period is calculated from the measurement of esophageal pressure and tidal volume (composite outcome).
- Secondary Outcome Measures
Name Time Method Blood gases 10 minutes Arterial or capillary blood gases at the end of each period
Comfort of breathing 10 minutes Subjective evaluation at the end of each period
Tidal Volume 10 minutes Measured at the end of each period
End-tidal carbon dioxide 10 minutes Measured at the end of each period
Dyspnea 10 minutes Evaluation on a borg scale at the end of each period
Respiratory Rate 10 minutes Measured at the end of each period
Oxygen saturation 10 minutes Measured at the end of each period
Esophageal pressure-time product 10 minutes Measured at the end of each period
Heart rate 10 minutes Measured at the end of each period
Trial Locations
- Locations (1)
Centre de Recherche de l'IUCPQ
🇨🇦Québec, Quebec, Canada