Taurine as a Possible Anti-aging Therapy?
- Conditions
- Oxidative Stress
- Interventions
- Dietary Supplement: PlaceboDietary Supplement: Taurine
- Registration Number
- NCT05149716
- Lead Sponsor
- University of Sao Paulo
- Brief Summary
Among the strategies that can improve the body's ability to counteract oxidative stress, the use of nutritional antioxidants has been investigated. Taurine is a "semi-essential" amino acid, also called a nitrogen compound, which has been used as an effective antioxidant due to its ability to neutralize hypochlorous acid, an extremely toxic oxidant produced by leukocytes in the inflammatory process in humans.
- Detailed Description
Objective: To evaluate the oxidative parameters of women aged 55 to 70 years after 16 weeks of taurine supplementation.
Methods: Twenty-four women age 55 to 70 will be randomly assigned to two groups: control group (GC), supplemented with placebo (1.5 g of starch); and taurine group (GTAU), supplemented with taurine (1.5 g), for 16 weeks. Anthropometry, functional capacity test, taurine, and levels of oxidative stress markers will be determined in pre and post intervention plasma samples. Food consumption will be assessed before, during, and after the intervention. The results will be analyzed by an ANOVA two-way repeated measures mixed model, with the Sidak post hoc (p \< 0.05).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 24
- Had being aged 55-70 years;
- Female;
- Post-menopausal;
- Sedentary (not practicing physical exercise for at least 6 months).
- Chronic kidney diseases;
- Infectious contagious diseases;
- Coronary heart disease;
- Smokers
- Alcoholics.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo supplementation Placebo Placebo supplementation composed of capsules of starch powder. Dosage: 1.5 gram/day Frequency: 1 time/day Duration: 16 weeks Taurine supplementation Taurine Taurine supplementation composed of capsules of taurine powder. Dosage: 1.5 gram/day Frequency: 1 time/day Duration: 16 weeks
- Primary Outcome Measures
Name Time Method Change from baseline in blood oxidative stress marker measurement - Glutathione reductase (GR). sixteen weeks Glutathione reductase (GR) activity was determined by the spectrophotometric method at 37 ºC/340nm after the oxidation of NADPH in the presence of oxidized glutathione, and were calculated at 16 weeks in comparision to the baseline.
Change from baseline in blood oxidative stress marker measurement - Superoxide Dismutase (SOD). sixteen weeks The superoxide dismutase (SOD) activity in erythrocytes was evaluated by the spectrophotometric method, and were calculated at 16 weeks in comparision to the baseline.
Change from baseline in blood oxidative stress marker measurement - Malondialdehyde (MDA). sixteen weeks The malondialdehyde (MDA) were calculated at 16 weeks in comparision to the baseline.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Escola de Educação Física e Esporte de Ribeirão Preto
🇧🇷Ribeirao Preto, Sao Paulo, Brazil