Can Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) be Used as Inflammatory Markers to Predict Length of Hospital Stay After Total Laparoscopic Hysterectomy (TLH) for Benign Indications?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 主要终点
- Postoperative PLR values compared in patients who were hospitalized for more than 3 days and equal to or less than 3 days.
研究概览
简要总结
Due to short hospital stay, rapid return to work, less pain, and good cosmetic results, laparoscopic hysterectomy ( LH) has substantially increased the era of hysterectomy procedures especially for the last two decades. The main reason for this is probably that LH leads to fewer inflammatory responses when compared to open abdominal hysterectomy. Although the inflammatory response is supposed to be lower with total laparoscopic hysteroscopy (TLH), unpredictable inflammatory response as a result of the operation has been still unenlightened and it can be associated with hospital stay.
详细描述
IInflammatory response after surgery is an ordinary outcome which ends up with tissue repair. The increase in neutrophil levels accompanied with a decrease in lymphocyte levels is characteristic for the inflammatory response. Therefore, neutrophil to lymphocyte ratio (NLR) comes out as a simple index of inflammation. In the literature, NLR was shown not only to be associated with surgical complications but also the length of hospital stays in certain surgeries. Another inflammatory marker index of hemogram is the platelet to lymphocyte ratio (PLR). As a result of endothelial tissue damage, platelets are gathered in the affected area. Therefore, an increase in the number of platelets is inevitable for inflammation. Hence, PLR appears to be another simple index of inflammation due to the increase of platelets and the decrease of lymphocytes. PLR has also shown to be associated with length of hospital stay in various surgeries. NLR and PLR are both newly recommended inflammatory markers to estimate the prognosis of surgical treatment in clinics. Investigations regarding NLR and PLR concerning prognosis of patients after surgeries including gynecological cancer, cardiac surgeries, and emergency surgeries are available in prior literature. Investigators aimed to investigate the possible effects of inflammatory parameters, that can be easily obtained from complete blood count in the post-operative first day of total laparoscopic hysterectomy, to the length of hospital stay in patients without any complications.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patients whom have undergone TLH
排除标准
- •Ureter injury
- •Bladder injury,
- •Bowel injury,
- •Superficial inferior mesenteric artery injury
- •Vaginal cuff hematoma
- •Vaginal cuff dehiscence
- •Endometriosis
- •Endometrial cancer
- •Cervical cancer
- •Chronic lymphocytic leukemia
- •Behçet disease
- •Electrolyte imbalance
- •Thyroid disease
- •Using anti-inflammatory medications
- •Having severe intraabdominal adhesions
结局指标
主要结局
Postoperative PLR values compared in patients who were hospitalized for more than 3 days and equal to or less than 3 days.
时间窗: 4 years
PLR were calculated by dividing the absolute number of platelets to the absolute number of lymphocytes.
Postoperative NLR values compared in patients who were hospitalized for more than 3 days and equal to or less than 3 days.
时间窗: 4 years
NLR was calculated by dividing the absolute number of neutrophil to the absolute number of lymphocytes.
次要结局
未报告次要终点
研究者
Fatma ketenci gencer
Dr.
Gaziosmanpasa Research and Education Hospital