Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio

Completed

• Conditions: Anesthesia; Inflammation
• Interventions: Procedure: peripheral nerve block

• Registration Number: NCT05628935
• Lead Sponsor: Zonguldak Bulent Ecevit University

Brief Summary

The neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of the inflammatory response. NLR is affected not only by surgical trauma but also by the anesthetic method. The method of anesthesia can affect NLR, thereby modulating the inflammatory response and surgical outcomes. In this study, it was aimed to evaluate the relationship between blood NLR and anesthesia techniques in patients undergoing forearm surgery, and the secondary aim was to evaluate the relationship between Platelet/lymphocyte ratio (TLR), Mean Platelet Volume (MPV) and anesthesia techniques.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-01
• Primary Completion: 2020-11-01
• Study Completion: 2021-11-01
• Status Verified: 2022-11
• Study First Submitted: 2022-11-17
• Study First Submitted QC: 2022-11-28
• Last Update Submitted: 2022-11-28
• Study First Posted: 2022-11-29
• Last Update Posted: 2022-11-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

• Underwent forearm surgery
• Between aged 18-70
• Under general anesthesia or peripheral nerve block

Exclusion Criteria

• acute infection
• morbid obesity
• chronic treatment with steroids or immunosuppressants
• recently received chemotherapy
• hepatic and renal dysfunction;
• chronic alcohol abusers
• Multiple trauma
• Patients with missing data in their files

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group P	peripheral nerve block	Patients Undergoing Forearm Surgery under peripheral nerve block

Primary Outcome Measures

Name	Time	Method
Neutrophil/lymphocyte ratio	up to 24 hours after surgery	Differences in neutrophil-lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block

Secondary Outcome Measures

Name	Time	Method
Platelet/lymphocyte ratio	up to 24 hours after surgery	Differences in Platelet/lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block
Mean Platelet Volume	up to 24 hours after surgery	Differences in Mean Platelet Volume between patients who underwent general anesthesia and peripheral nerve block

Trial Locations

Locations (1)

Zonguldak Bülent Ecevit University Medicine Faculty; 🇹🇷 Zonguldak, Kozlu, Turkey