The Effect of Preoperative NLR Level on Epidural Analgesia Application in Thoracotomy

Completed

• Conditions: C23.550.470; C23.550.767.700
• Interventions: Diagnostic Test: Neutrophil Lynphosite ratio

• Registration Number: NCT05209958
• Lead Sponsor: Karadeniz Technical University

Brief Summary

The aim of this study is to investigate the relationship of preoperative Neutrophil/Lymphocyte Ratio (NLR) with postoperative pain and the effect of preoperative NLR level on timing of epidural analgesia in thoracotomy.

Detailed Description

The study was conducted prospectively in 60 patients aged 18-75 years, ASA I-III, who underwent thoracotomy. The patients were divided into 2 groups as NLR level above 2 (Group A) (n:32) and NLR level below 2 (Group B) (n:28). Each group was divided into subgroups with equal numbers of Prempative analgesia group and control group. Local anesthetic was administered to the preemptive analgesia group (Group P) 20 minutes before the surgical incision through the epidural catheter, and to the control group (Group K) 20 minutes before the patient was awakened from the epidural catheter. NRS levels and additional analgesia needs were recorded at 2, 4, 8, 12 and 24 hours postoperatively.

Study Timeline

• Study Start: 2020-06-10
• Primary Completion: 2021-09-01
• Status Verified: 2022-01
• Study Completion: 2022-01-10
• Study First Submitted: 2022-01-10
• Study First Submitted QC: 2022-01-22
• Last Update Submitted: 2022-01-22
• Study First Posted: 2022-01-27
• Last Update Posted: 2022-01-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patient graded as American Society of Anesthesiologist (ASA) physical status, I, II or III
• Patient subjected to thoracotomy operation

Exclusion Criteria

Patient having morbid obesity,

• Patient having renal failure,
• Patient having hepatic failure,
• Patient having neuropsychiatric disease,
• Patient allergy to the study drugs

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group A	Neutrophil Lynphosite ratio	Patients with NLR level below 2
Group B	Neutrophil Lynphosite ratio	Patients with NLR level equal to or above 2

Primary Outcome Measures

Name	Time	Method
preoperative neutrophil lymphoycte ratio	24 hours before the operation	To determine the epidural application with preoperative neutrophil lymphoycte ratio
Postoperative opioid requiremen Postoperative opioid requirement	postoperative first 24 hour	Postoperative opioid requirement for pain relief

Secondary Outcome Measures

Name	Time	Method
Numerical Pain Rating Scale	postoperative first 24 hour	Numerical Pain Rating Scale in postoperative period

Trial Locations

Locations (1)

KaradenızTU; 🇹🇷 Trabzon, Turkey