Neutrophil-to-lymphocyte and Platelet-to-lymphocyte Ratio in Predicting the Incidence of Nausea and Vomiting

Not yet recruiting

• Conditions: Hemophilia A

• Registration Number: NCT05636163
• Lead Sponsor: Qianfoshan Hospital

Brief Summary

By comparing the incidence of PONV, the dosage of postoperative antiemetic drugs, the postoperative VAS score and the utilization rate of PCIA of hemophilia A patients in the NLR≥2 and NLR\<2 groups, investigators could find out the high value in the diagnosis of hemophilia A, which is helpful to guide the clinical diagnosis and treatment of hemophilia A.

Detailed Description

Hemophilia arthropathy is a debilitating complication of hemophilia that occurs primarily in severe forms with recurrent spontaneous intra-articular hemorrhage, with the knee being the most commonly affected joint. Currently, total knee arthroplasty is the standard treatment for end-stage hemophilic arthropathy. Due to the special disease of hemophilia, general anesthesia is often chosen as the preferred anesthesia method, and the risk of bleeding is lower than that of neuraxial anesthesia. However, 20 to 30 percent of surgical patients suffer from post-operative nausea and vomiting after general anesthesia. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio have been suggested as parameters for the diagnosis and follow-up of inflammatory diseases, and inflammation has been found to increase the risk of PONV. However, for patients with hemophilia, no information is currently available on the relationship between the two. In this study, investigators intend to retrospectively analyze the clinical data of patients with hemophilia A in our hospital, explore the clinical value of preoperative NLR and PLR in predicting nausea and vomiting after TKA.

Study Timeline

• Study First Submitted: 2022-11-17
• Status Verified: 2022-12
• Study First Submitted QC: 2022-12-02
• Last Update Submitted: 2022-12-02
• Study First Posted: 2022-12-05
• Last Update Posted: 2022-12-05
• Study Start: 2022-12-15
• Primary Completion: 2023-01-20
• Study Completion: 2023-02-20

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Male
• Target Recruitment: 120

Inclusion Criteria

1. The patients with hemophilia A undergoing unilateral total knee arthroplasty.
2. The age of the patients ranged from 18 to 70 years.
3. American Society of Anesthesiologists is graded as I~III
4. No history of mental illness
5. No history of antiemetic and anticholinergic drugs.
6. No history of serious gastrointestinal diseases.

Exclusion Criteria

1. Patients who have received long-term steroid treatment
2. Patients who need more than 2.5 mg neostigmine to reverse muscle relaxants
3. Patients with previous malignant tumor, malabsorption, morbid obesity, hypogonadism, thyroid and parathyroid diseases and autoimmune diseases.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of PONV in patients with hemophilia A receiving general anesthesia orders for knee arthroplasty	up to 24 hours after surgery	PONV was defined as the onset of nausea or vomiting within 24 hours after surgery

Secondary Outcome Measures

Name	Time	Method
The amount of postoperative antiemetics	up to 24 hours after surgery	antiemetics includes ondansetron, metoclopramide, dexamethasone
VAS score after returning to the ward	immediately after returning to the ward	postoperative pain can be evaluated using the visual analogue scale (0-10 score, 0: no pain, 10: worst imaginable pain).
Usage of PCIA	up to 24 hours after surgery	the use of postoperative patient controlled intravenous analgesia

Trial Locations

Locations (1)

Shandong Provincial Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University; 🇨🇳 Jinan, Shandong, China