A Multicenter, Single-arm, Open-label Clinical Trial of Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy, HLX07 and Serplulimab in the Treatment for RAS/BRAF Wild Type Locally Advanced Rectal Cancer
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Rectal Cancer
- Sponsor
- Wuhan Union Hospital, China
- Enrollment
- 29
- Locations
- 1
- Primary Endpoint
- complete response (CR) rate
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The study is a multicenter, open-label, phase II clinical study, and the purpose of the study is to explore the complete response rate (CR, Defined as pathological complete response (pCR) + Clinical complete response (cCR)) of patients with RAS/BRAF wild type locally advanced rectal cancer(LARC) treated with short-term radiotherapy, sequential HLX07, Serplulimab and CAPOX. A total of 29 patients were included in this study.
Detailed Description
Patients with RAS/BRAF wild type locally advanced rectal cancer (T3-4/N+) , combined risk factors, will be treated with neoadjuvant therapy, and the Primary endpoint of the study is complete response rate(CR, Defined as pathological complete response (pCR) + Clinical complete response (cCR) ). PCR assessed by the blind independent review committee (BIRC), defined as the absence of viable tumour cells in the resected primary tumour specimen and all sampled regional lymph nodes (ypT0N0). CCR evaluation was based on a combination of digital rectal examination, endoscopy, rectal MRI and blood carcinoembryonic antigen levels.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients or their family members agree to participate in the study and sign the informed consent form;
- •Age 18-75 years, male or female;
- •Histologically confirmed Locally Advanced rectal adenocarcinoma
- •Genetic test and/or immunohistochemical confirmation of RAS, BRAF wild type
- •inferior margin ≤ 10 cm from the anal verge;
- •Pelvic MRI shows high risk \[meets one of the following conditions\]:
- •Clinical tumor (cT) staging cT4a or cT4b (according to AJCC 8th Edition)
- •Extramural vascular infiltration
- •Clinical lymph node (cN) staging cN2 (according to AJCC 8th Edition)
- •Mesenteric fascia is involved
Exclusion Criteria
- •Documented history of allergy to study drugs, including any component of Anti-EGFR or PD-1 antibody, capecitabine, oxaliplatin and other platinum drugs;
- •Have received or are receiving any of the following treatments:
- •Any radiotherapy, chemotherapy or other anti-tumor drugs for tumor; Patients who need to be treated with corticosteroid (dose equivalent to prednisone of \>10 mg/day) or other immunosuppressive agents within 2 weeks prior to study drug administration; Received live attenuated vaccine within 4 weeks before the first use of the study drug; Major surgery or severe trauma within 4 weeks before the first use of the study drug;
- •Any active autoimmune disease or history of autoimmune disease;
- •Have a history of immunodeficiency, including HIV positive, or other acquired or congenital immunodeficiency diseases, or have a history of organ transplantation or allogeneic bone marrow transplantation;
- •There are clinical symptoms or diseases of heart that are not well controlled;
- •Severe infection (CTCAE \> 2) occurred within 4 weeks before the first use of the study drug; Baseline chest imaging revealed active pulmonary inflammation, signs and symptoms of infection within 14 days prior to the first use of the study drug, or oral or intravenous antibiotic therapy, except for prophylactic use of antibiotics;
- •Patients with active pulmonary tuberculosis infection found by medical history or CT examination, or with a history of active pulmonary tuberculosis infection within one year before enrollment, or with a history of active pulmonary tuberculosis infection more than one year ago but without regular treatment;
- •The presence of active hepatitis B (HBV DNA \> 2000 IU/mL or 104 copies/mL) was positive for hepatitis C (hepatitis C antibody) and HCV RNA was higher than the lower limit of analytical method;
- •Female subject who is pregnant or breastfeeding;
Outcomes
Primary Outcomes
complete response (CR) rate
Time Frame: an expected average of 12 months
Defined as pathological complete response (pCR) + Clinical complete response (cCR)
Secondary Outcomes
- 3-year disease-Free Survival(an expected average of 3 years)
- Overall Survival(an expected average of 5 years)
- dverse events (AEs) were graded according to the NCI CTCAE version 5·0(an expected average of 1.5 years)