NCT00293280已完成2 期
Phase II Study of CCNU (Lomustine) in Patients With Advanced Non-Small Cell Lung Cancer and Aberrant Hypermethylation of the MGMT Gene
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins2 个研究点 分布在 1 个国家目标入组 42 人开始时间: 2005年7月最近更新:
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 2
- 主要终点
- Response rate
研究概览
简要总结
RATIONALE: Drugs used in chemotherapy, such as lomustine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
PURPOSE: This phase II trial is studying how well lomustine works in treating patients with stage III or stage IV non-small cell lung cancer.
详细描述
OBJECTIVES:
Primary
- Evaluate the response rate to lomustine in patients with stage IIIB or IV non-small cell lung cancer with aberrant methylation of the MGMT gene.
- Determine whether the response rate in these patients is significantly greater than that of the historical control.
Secondary
- Collect preliminary data on toxicity, disease stabilization, time to disease progression, and overall survival.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Response rate
次要结局
- Association between clinical outcome and immunohistochemical staining
- Toxicity
- Disease stabilization
- Overall survival
- Time to disease progression
研究者
研究点 (2)
Loading locations...
相似试验
终止
2 期
Fotemustine in Treating Patients With Metastatic MelanomaMelanoma (Skin)NCT00560118Institut du Cancer de Montpellier - Val d'Aurelle12
撤回
2 期
S0902 Bendamustine and Rituximab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia That Has Not Responded to Previous TreatmentLeukemiaNCT00939328SWOG Cancer Research Network
已完成
1 期
Bendamustine and Erlotinib in Treating Patients With Stage IIIB, Stage IIIC, or Stage IV Breast CancerBreast CancerNCT00834678Ohio State University Comprehensive Cancer Center11
已完成
2 期
Bendamustine as Second-Line Therapy in Treating Patients With Relapsed or Refractory Small Cell Lung CancerLung CancerNCT00984542Vanderbilt-Ingram Cancer Center50
已完成
1 期
Bendamustine and Radiation Therapy in Treating Patients With Brain Metastases Caused by Solid TumorsMetastatic CancerUnspecified Adult Solid Tumor, Protocol SpecificNCT00837928John Grecula18