Do maneuvers to re-inflate collapsed areas of lung during surgery for lung cancer help to improve post-operative oxygen levels?

Not Applicable

• Conditions: ung cancer surgery; Lung cancer surgery; Anaesthesiology - Anaesthetics; Cancer - Lung - Non small cell; Cancer - Lung - Small cell

• Registration Number: ACTRN12612000274875
• Lead Sponsor: Dr Marissa Ferguson

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-03-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Patients undergoing elective thoracic surgery with one lung ventilation for cancer resection (wedge resection or lobectomy).
Age > 18 years.

Exclusion Criteria

Patients who are not competent to consent for themselves.
Patients under the age of 18 years.
Pregnant women.
Pre-operative haemodynamic instability.
Intra-operative blood loss >500ml.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Post-operative arterial oxygenation as assessed by arterial blood gas machine.[1 hour, 4 hours, 24 horus, and 48 hours post-operatively.]

Secondary Outcome Measures

Name	Time	Method
Post-operative acute lung injury or acute respiratory distress syndrome, as defined by the American-European consensus criteria for ALI/ARDS.[Any time within the post-operative period whilst an inpatient in hospital.];Post-operative respiratory failure requiring re-intubation.[Any time within the post-operative period whilst an inpatient in hospital.];Atelectasis detected on post-operative chest x-rays.[Development of atelectasis at any time during the post-operative period whilst an inpatient, as assessed on chest x-rays performed as part of routine care.];Post-operative pneumonia, defines as: 'Pulmonary infiltrates that are new or progressing on chest x-ray, plus findings suggesting inflammation (new onset fever, purulent sputum, leucocytosis, and/or positive sputum culture).'[Any time within the post-operative period whilst an inpatient in hospital.];Post-operative inflammation, measured by serum cytokines[24 hours post-operatively]