A Pilot, Randomised, Blinded, Feasibility, Safety and Biochemical and Physiological Efficacy Study of Terlipressin vs. Placebo in Cardiac Surgery Patients with the Post-operative High Cardiac Output and Hypotension syndrome

Phase 4

• Conditions: Post-operative high cardiac output and hypotension syndrome in patients following cardiac surgery; Surgery - Other surgery; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12613001194752
• Lead Sponsor: Austin Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-10-30
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patients aged 18 years or older
- Admitted to the intensive care unit after cardiopulmonary bypass
- High cardiac index (greater than 3 litres/minute/m2)
- Hypotension (systolic blood pressure less than 90 mmHg or mean arterial blood pressure less than 65 mmHg)

Exclusion Criteria

- Pregnancty
- Death is considered imminent (within 24 hours)
- Known sever peripheral vascular disease
- Raynaud's phenomenon
- Known allergy to terlipressin
- Unstable angina
- Recent myocardial infarction
- Asthma
- Surgery for coronary artery disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified