Dynamic Plantar Microvascular Skin Response to Compressive Loads in At-risk Diabetic and Healthy Control
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Foot Ulcer, Diabetic
- Sponsor
- Temple University
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Latency time after occlusive loading
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this pilot study is to compare the dynamic response of microcirculation in the skin on the bottom of the big toe after applying controlled plantar stress in 25 diabetic subjects with a history of foot ulcer and 25 age-matched healthy controls to better understand the role of local hypoxia in neuropathic foot ulceration in subjects with diabetes.
The investigators hypothesize that if they apply a gait simulating load to the plantar foot and measure microvascular function, diabetic individuals will demonstrate an increased delay in reestablishing microvascular flow compared to healthy individuals.
Investigators
Eligibility Criteria
Inclusion Criteria
- •between ages 40 and 75
- •history of diabetic neuropathic plantar ulcer (test subjects)
- •no history of diabetes (control subjects)
- •no peripheral sensory neuropathy (control subjects)
Exclusion Criteria
- •amputation or surgery on right Great Toe
Outcomes
Primary Outcomes
Latency time after occlusive loading
Time Frame: approximately 2.75 minutes after start of collection protocol
The time between removal of occluding pressure and the initiation of the post-occlusive hyperemic response as measured by laser Doppler.
Secondary Outcomes
- Response time to baseline(2.75 seconds after start of collection protocol)
- Response time to Maximum Flow(At least 2.75 seconds after the start of collection protocol.)