A clinical trial to study the effects of dexmedetomidine drug on laryngoscopy and tracheal intubation during the administration of general anesthesia.
Phase 4
Completed
- Registration Number
- CTRI/2013/08/003885
- Lead Sponsor
- Govt Medical College and Hospital Sector Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
1.80 adult patients of ASA (American Society of Anesthesiologists) physical status I /II of either sex
2.Age group of 18 to 60 years
3.Scheduled to undergo elective surgery under general anaesthesia requiring endotracheal intubation
Exclusion Criteria
The following categories of patients were excluded from the study:
1.ASA grade III or more
2.Anticipated difficult airway
3.BMI >30 kg m 2
4.Preoperative medication with clonidine or alphamethyldopa
5.Hiatus hernia, gastroesophageal reflux
6.Known allergy to dexmedetomidine
7.Known case of coronary artery disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To study the effect of dexmedetomidine given before induction of anaesthesia on haemodynamic responses to direct laryngoscopy and tracheal intubation.Timepoint: Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Blood Pressure (MBP), Oxygen Saturation (SpO2), end tidal CO2 (EtCO2) were continuously monitored and recorded at following time intervals. <br/ ><br>-Baseline <br/ ><br>-After completion of infusion of study drug <br/ ><br>-5 min after completion of infusion of study drug <br/ ><br>-After induction <br/ ><br>-Just before intubation <br/ ><br>-After intubation at 1min, 3min, 5min, 10min and 15 min. <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1)To study effect of dexmedetomidine on requirement of propofol at induction. <br/ ><br>2)To study the adverse effects of dexmedetomidine. <br/ ><br>Timepoint: -After recording the primary outcome observations for 15 the rest of the anaesthetic procedure was carried out. The secondary outcomes were recorded during the study which includes the the total dose of propofol required for induction and any adverse effects of dexmedetomidine during the entire study was recorded.