A Retrospective Cohort Study of Patients Who Underwent Curative-intent Esophagectomy for ESCC at a Tertiary Referral Center in South Korea

Completed

• Conditions: Oesophageal Squamous Cell Carcinoma

• Registration Number: NCT07201571
• Lead Sponsor: Samsung Medical Center

Brief Summary

This retrospective cohort study was conducted using the Registry for Thoracic Cancer Surgery at Samsung Medical Center (Seoul, South Korea), which has included all patients who underwent thoracic surgery

Detailed Description

This retrospective cohort study was conducted using the Registry for Thoracic Cancer Surgery at Samsung Medical Center (Seoul, South Korea), which has included all patients who underwent thoracic surgery

Study Timeline

• Study Start: 1994-11-06
• Primary Completion: 2025-08-31
• Study Completion: 2025-08-31
• Status Verified: 2025-09
• Study First Submitted: 2025-09-23
• Study First Submitted QC: 2025-09-23
• Last Update Submitted: 2025-09-23
• Study First Posted: 2025-10-01
• Last Update Posted: 2025-10-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 3131

Inclusion Criteria

• Patients who underwent curative surgery for esophageal cancer

Exclusion Criteria

• cervical esophageal cancer
• gastroesophageal junction cancer
• histology other than squamous cell carcinoma
• patients with Child-Pugh class B or C liver cirrhosis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative complications	within 90 days after surgery	Complications related to fluid imbalance and portal hypertension, such as ascites, pleural effusion, and chyle leak; complications associated with impaired renal or hematologic function, including acute kidney injury, bleeding, and graft failure; and complications reflecting immune dysfunction and infection susceptibility, including pneumonia and empyema. Complications associated with impaired tissue healing, such as anastomotic leakage, were also analyzed. Liver failure and acute respiratory distress syndrome were considered separately. All complications were defined according to the Esophageal Complications Consensus Group, and their severity was assessed according to the Clavien-Dindo classification.

Secondary Outcome Measures

Name	Time	Method
Overall survival	10 years after surgery	Interval from the date of surgery to death or censoring