Effect of two markers sTREM-1 and TNF - alpha in GCF OF periodontal health and periodontitis with and without type 2 diabtes mellitus

Not Applicable

• Conditions: Health Condition 1: E119- Type 2 diabetes mellitus without complications

• Registration Number: CTRI/2023/03/050308
• Lead Sponsor: ARYA DEVI S

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 3 April 2023

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

a) Age group of 20 â?? 60 years of either sex.

b) Patients with diagnosis of Type 2 Diabetes Mellitus, based on the parameters- fasting plasma glucose ( FPG) >= 126 mg/dl or 2 hour plasma glucose ( PG) >= 200 mg / dl, or HbA1C ( glycated haemoglobin ) >= 6.5 % or random plasma glucose >= 200 mg / dl, as per 2019 American Diabetes Association classification.

c) Individuals with healthy periodontium,

d) Patients with diagnosis of generalized stage III grade B periodontitis, as per 2017

World Workshop on classification of periodontal and peri-implant diseases and

conditions.

e) Individuals who smoke < 10 cigarettes per day.

f) Presence of at least 20 natural teeth.

Exclusion Criteria

a) Patients with any systemic diseases other than Type 2 Diabetes Mellitus.

b) Those who have undergone periodontal therapy in last six months preceding the start of the study.

c) Individuals who have history of any antimicrobial or anti- inflammatory therapy in the last six months.

d) Pregnant, lactating and postmenopausal women.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. To estimate the levels of sTREM-1 and TNF -α in GCF of subjects with health and generalized stage III grade B periodontitis with and without Type 2 Diabetes Mellitus. <br/ ><br> <br/ ><br>2. To correlate the levels of sTREM-1 and TNF- α in GCF of subjects with health and generalized stage III grade B periodontitis with and without Type 2 Diabetes MellitusTimepoint: At baseline

Secondary Outcome Measures

Name	Time	Method
3. To explore the possibility of using sTREM-1 and TNF-α as a marker for health, Type 2 Diabetes Mellitus and generalized stage III grade B periodontitis and relate them with clinical parameters.Timepoint: At baseline