Evaluation of topical ozonated olive oil gel on socket healing after surgical extraction of impacted molars

Not Applicable

• Conditions: Promote bone and soft tissues healing and prevent alveolitis after surgical extraction of 3rd mandibular molar; Oral Health

• Registration Number: ISRCTN14639952
• Lead Sponsor: Damascus University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-05-22
• Last Update Posted: 5 June 2023
• Study Completion: 2023-10-10

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

1. Aged between 18 - 35 years old
2. Patients with symmetrically impacted mandibular third molar on both sides and of the same classification according to Pell & Gregory
3. Classification of general health status: ASA I (a normal, healthy, non-smoking patient with a normal body mass index) (American Society of Anesthesiologists, 2020)
4. Patients who are cooperative, have good mental ability and are committed to periodic reviews, postoperative recommendations and oral care
5. No previous surgical treatment of the target area
6. Patients with good oral health and healthy periodontal tissues

Exclusion Criteria

1. Patients with systemic disease affecting wound healing
2. Patients with fungal lesions in oral cavity
3. Presence of a periodontal injury in the lower second molar
4. Psychologically unstable patients
5. Patients who smoke
6. Uncooperative patients
7. The presence of local pathogens around the impacted molars, such as large cysts and tumors
8. The presence of any local or general contraindications to the use of ozonted olive oil gel such as systemic diseases, G6PD deficiency, or a history of allergy, local infection, a pregnant woman or using contraceptive drugs or breastfeeding, as well as recent myocardial infarction
9. Severe anemia
10. Hyperthyroidism

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Bone density measured using cone beam computed tomography (CBCT) imaging and ITK-SNAP software analysis at (t1) 6 weeks and (t2) 3 months after surgery<br> 2. Soft tissue healing measured using Landry's index 7 days after surgery<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. Measurements using a periodontal probe at (t0) before surgery and (t2) 3 months after surgery<br> 1.1. Probing depth (PD)<br> 1.2. Gingival overgrowth (GO)<br> 1.3. Clinical attachment level (CAL)<br> 2. Incidence of alveolitis measured using the Blum index 7 days after surgery<br>