Effects of Whole-Body Vibration Exercise on Serum IGF-1 in Fibromyalgia

Not Applicable

Completed

• Conditions: Fibromyalgia; Hormonal Responses to Exercise in Patients With Fibromyalgia.
• Interventions: Device: Vibratory platform, PowerPlate®, Badhoevendorp, Netherlands; Device: Placebo Whole-body vibration exercise

• Registration Number: NCT00650715
• Lead Sponsor: Institut Nacional d'Educacio Fisica de Catalunya

Brief Summary

The purpose of this study was to investigate the acute and chronic effect of whole-body vibration exercise on serum insulin-like growth factor-1 levels in women with fibromyalgia (FM). It was hypothesized that women with FM would exhibit an increase in IGF-1 following both acute and chronic WBV. Twenty-four women with FM were randomized into two groups: Vibration Group (VG) and Control Group (CG). The VG underwent a protocol with WBV exercise twice a week for a total of six weeks, whereas the CG performed the same protocol without vibratory stimulus. Both groups continued with their usual pharmacological treatment. Serum IGF-1 levels were determined using Enzyme-Linked Immunosorbent Assay (ELISA). To test the effect of chronic WBV, serum IGF-1 measurements were taken at baseline and at weeks 1,3, and 6 of intervention. To test the effect of acute WBV, within week 1, serum IGF-1 measurements were taken before and immediately following a session of WBV.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-12
• Primary Completion: 2005-01
• Study Completion: 2005-01
• Status Verified: 2008-03
• Study First Submitted: 2008-03-31
• Study First Submitted QC: 2008-03-31
• Last Update Submitted: 2008-03-31
• Study First Posted: 2008-04-02
• Last Update Posted: 2008-04-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 24

Inclusion Criteria

• Patients diagnosed of fibromyalgia according to the American College of Rheumatology criteria for at least three years.

Exclusion Criteria

• Orthopedic limitation, or cardiovascular, pulmonary, or metabolic disease that would preclude exercise.
• Participation in any other study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
VG	Vibratory platform, PowerPlate®, Badhoevendorp, Netherlands	Vibration Group (VG) underwent a protocol with whole-body vibration exercise twice a week for a total of six weeks. The group continued with their usual pharmacological treatment.
CG	Placebo Whole-body vibration exercise	The Control Group (CG) underwent the same protocol of exercises than VG but without vibratory stimulus. The CG continued with their usual pharmacological treatment.

Primary Outcome Measures

Name	Time	Method
Serum IGF-1 levels	Baseline, Week 1, Week 3, Week 6

Trial Locations

Locations (1)

Institut Nacional d'Educación Física de Catalunya; 🇪🇸 Barcelona, Spain