Effects of Whole-body Vibration in the Frail Elderly
- Conditions
- Sarcopenia;Osteoporosis
- Interventions
- Procedure: WBV trainingProcedure: PRT training
- Registration Number
- NCT02090192
- Lead Sponsor
- Li Zhang
- Brief Summary
Objective: To study the acute and chronic effects of whole-body vibration (WBV) exercises on the lower extremity blood flow, mobility function, balance, muscle strength, bone density, and general health status, and its feasibility as an intervention in frail elderly patients.
Design: Randomized controlled trial. Subjects: The frail older persons meeting the Fried Frailty Criteria.
Interventions: All eligible subjects were randomly assigned to 4 groups:
(1) WBV group: Subjects received a whole-body vibration exercise alone; (2) Progressive resistance training (PRT) group: Subjects received progressive resistance training; (3) WBV+ PRT group: Subjects received the whole-body vibration and progressive resistance training; (4) Control group: Subjects received no intervention/training. The periods of intervention are 12 weeks.
Main measures: The lower extremities blood flow (the diameters and red blood cell velocity of the common femoral artery), timed up and go test, 30-second chair stand test, five times sit to stand test, lower extremities muscle strength, balance function, balance confidence, bone density, and general health status was assessed at the beginning of the study, at instant, 12 weeks and 24 month after the intervention.
Study hypothesis: Whole-body vibration exercise is a safe and effective method that can improve the lower extremity blood flow, mobility function, balance, muscle strength, bone density, and general health status in the frail elderly.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 160
- ≥75 years old
- Fried Frailty Criteria
- Mini Mental State Examination score ≥18
- Recent fractures (≤6 months)
- Gallbladder or kidney stones
- Malignancies
- Rheumatic arthritis
- Epilepsy
- Serious heart sicknesses or an implant, and bypass stent or cardiac pacemaker
- Any diseases to be associated with a life expectancy of less than 12 months
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description WBV training WBV training Whole-body vibration training was performed on a commercial Galileo machine (Germany). Participants were required to stand on the moveable rectangular platform and positioned their feet at an equal and standardized distance from the axis of rotation so that the vertical vibration amplitude was 1-3 mm. The frequency was set at 6-26 Hz. The vibration protocol consisted of four to five bouts (60 seconds for each bout), and three to five times a week for 12 weeks. The positions taken by the subjects differed according to their function. Participants who could stand independently were instructed to adopt a "partial squat" position with slight flexion at the hips, knees, and ankle joints to damp the vibrations approximately at the pelvic level. WBV+ PRT training WBV training - WBV+ PRT training PRT training - PRT training PRT training -
- Primary Outcome Measures
Name Time Method Change of the common femoral artery's blood flow from Baseline to 60min post-WBV 60min post-WBV Change of lower extremities muscle strength from Baseline to 3 month post-WBV 3 month post-WBV Change of "timed up and go" test (TUGT) from Baseline to 3 month post-WBV 3 month post-WBV Change of 30-second chair stand test from Baseline to 3 month post-WBV 3 month post-WBV Change of balance function from Baseline to 3 month post-WBV 3 month post-WBV Change of balance confidence from Baseline to 3 month post-WBV 3 month post-WBV Change of bone density from Baseline to 6 month post-WBV 6 month post-WBV Change of general health status (SF-12 score) from Baseline to 6 month post-WBV 6 month post-WBV
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Rehabilitation Department, Nanlou, Chinese PLA general hospital
🇨🇳Beijing, Beijing, China