Pharmacokinetic-pharmacodynamic modeling of S(+)-KETamine in healthy volunteers

Not Applicable

Completed

• Conditions: Ketamine, analgesic; Signs and Symptoms; Analgesic

• Registration Number: ISRCTN20522161
• Lead Sponsor: eiden University Medical Centre (LUMC) (The Netherlands)

Brief Summary

2009 results in: https://www.ncbi.nlm.nih.gov/pubmed/19741495 (added 09/05/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-02-26
• Study Completion: 2008-02-01
• Last Update Posted: 27 May 2019

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

1. Healthy volunteers 18+

Exclusion Criteria

1. Obesity (Body Mass Index [BMI] more than 30)
2. Presence of medical disease (heart-, lung-, liver-, kidney-, neurological disease; diabetes m.; pyrosis; diaphragmatic hernia)
3. Presence of psychiatric disease
4. History of chronic alcohol or drug use
5. Allergy to study medications
6. Possibility of pregnancy
7. Lactation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Analgesia and plasma concentration of ketamine.

Secondary Outcome Measures

Name	Time	Method
Bowdle scale parameters.