Assessment of neurovascular function and cognition in adult patients with complex congenital heart disease

Not Applicable

Completed

• Conditions: Heart disease; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12617000896370
• Lead Sponsor: Dr Nicholas Collins

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-06-19
• Last Update Posted: 15 July 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Adult patients with complex congenital heart disease, having measurable ultrasound signal on both sides of the head. Control participants should be healthy and without heart disease.

Exclusion Criteria

Unable to obtain a measurable signal in both left and right MCA
History of cerebrovascular events, including transient ischemic attack.
Uncontrolled hypertension (>160/100mmHg) (measured at the visit to CNRC)
Pregnant women and people highly dependent on medical care.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cerebrovascular responsiveness (CVR) to cognitive testing at the level of the middle cerebral artery (MCA). <br>Using TCD ultrasound, changes in blood flow velocity in the MCA during cognitive testing will be measured. [Week 1, one visit only.]