Relationships between cerebrovascular function and the incidence and severity of headache in premenopausal women

niversity of Newcastle0 个研究点目标入组 79 人开始时间: 2018年7月23日最近更新: 2020年11月9日

适应症

试验速览

暂无简介。

•Women between age 25 and menopause (> 6 months cessation of menses)
•Blood pressure <160/100mmHg (determined at screening visit)
•For migraine group: Suffer from migraine/headache +/- 3 days from their period and/or ovulation (mid-cycle) in the previous three menstrual cycles, lasting 4-72 hours with at least two of these characteristics: unilateral location, pulsating or throbbing pain, pain of at least moderate intensity, or aggravated by or causing avoidance of physical activity (walking/ stair climbing). They should be free from headache attacks at other times of the cycle.

•Not fluent in reading and writing in English.
•No detectable transcranial Doppler (TCD) ultrasound signal in the middle cerebral artery on either side.
•TCD blood flow velocity >185 cm/s
•Liver or kidney disease
•Hysterectomy
•Malignant cancer
•Insulin-dependent diabetes
•Fibromyalgia
•Excessive alcohol intake (>15 drinks per week)
•Pregnancy or breastfeeding
•Major depression
•Neurological conditions including stroke, TIA, major depression, multiple sclerosis, epilepsy, Chiari malformation, Parkinson’s disease or dementia or mild cognitive impairment.
•Unwilling to provide a blood sample
•History of using Botulinum toxin or neuromodulation devices for treatment of headaches.

发起方

niversity of Newcastle