ACTRN12618001230246
Completed
未知
Relationships between cerebrovascular function and the incidence and severity of headache in premenopausal women
niversity of Newcastle0 sites79 target enrollmentJuly 23, 2018
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Migraine
- Sponsor
- niversity of Newcastle
- Enrollment
- 79
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Women between age 25 and menopause (\> 6 months cessation of menses)
- •Blood pressure \<160/100mmHg (determined at screening visit)
- •For migraine group: Suffer from migraine/headache \+/\- 3 days from their period and/or ovulation (mid\-cycle) in the previous three menstrual cycles, lasting 4\-72 hours with at least two of these characteristics: unilateral location, pulsating or throbbing pain, pain of at least moderate intensity, or aggravated by or causing avoidance of physical activity (walking/ stair climbing). They should be free from headache attacks at other times of the cycle.
Exclusion Criteria
- •Not fluent in reading and writing in English.
- •No detectable transcranial Doppler (TCD) ultrasound signal in the middle cerebral artery on either side.
- •TCD blood flow velocity \>185 cm/s
- •Liver or kidney disease
- •Hysterectomy
- •Malignant cancer
- •Insulin\-dependent diabetes
- •Fibromyalgia
- •Excessive alcohol intake (\>15 drinks per week)
- •Pregnancy or breastfeeding
Outcomes
Primary Outcomes
Not specified
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