Is dysfunction of brain blood vessels associated with cognitive impairment in type-1 diabetes?

Not Applicable

Completed

• Conditions: Type 1 Diabetes Mellitus; Metabolic and Endocrine - Diabetes; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12618000496213
• Lead Sponsor: niversity of Newcastle

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-04-05
• Study Completion: 2019-12-13
• Last Update Posted: 24 February 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Inclusion criteria for T1D:
Age 30 – 80 years old
T1D diagnosed before 18 years of age
No advanced diabetes complications such as blindness or deafness
Not hospitalised for severe glycemic events in the last 3 months

Inclusion criteria for control group:
No T1D or T2D diagnosis and HbA1c <6.5%
Not taking medication for hypertension and cholesterol

Exclusion Criteria

Not fluent in reading and writing in English
No detectable transcranial Doppler (TCD) ultrasound signal in the middle cerebral artery on either side.
Liver or kidney disease
Malignant cancer
Excessive alcohol intake (>15 drinks per week)
Pregnancy
Neurological conditions including stroke, TIA, major depression, multiple sclerosis, Parkinson’s disease or dementia or mild cognitive impairment.
Unwilling to provide a blood sample

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Composite Primary Outcome: Overall performance of a neuropsychological test battery, consisting of the Trail Making Task, the N-back task, Rey-Osterrieth complex figure, and the NIH Toolbox Battery of cognitive function.[Week 0 visit 1]