Investigation of cerebrovascular reactivity in post-COVID-19 syndrome using functional magnetic resonance imaging
- Conditions
- Post-COVID syndrome
- Registration Number
- DRKS00033075
- Lead Sponsor
- niversitätsklinikum Tübingen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 90
Willingness to provide the written informed consent and the ability to give consent.
-SARS-CoV-2 infection confirmed by PCR test at least 12 weeks ago and the presence of a clinical neurological post-COVID syndrome (depending on the subgroup, leading symptom complex fatigue/concentration and memory disorder/headache/dizziness or leading symptom complex myopathy/neuropathy).
-Inclusion criterion for the control group after SARS-CoV-2 infection without post-COVID syndrome is a SARS-CoV-2 infection at least 12 weeks ago, confirmed by PCR test.
-Contraindications against MRI examinations; if metallic foreign bodies are present, it is checked before the examination whether the materials used are MRI-compatible and the examination can take place without increased risk
- Persons with known ischemic infarcts, as well as known hemodynamically relevant extra- and intracranial and vascular diseases
- Persons with known neurological or psychiatric illnesses prior to infection with SARS-CoV-2
- Persons with illnesses that prevent them from lying quietly in the examination device for 60 minutes (e.g. pain, claustrophobia, limited temperature sensitivity and/or increased sensitivity to body heating)
- Persons who do not appear to be cognitively or cardiopulmonarily capable of taking short breaths lasting 9 seconds
- Persons whose pregnancy has not been ruled out with certainty
- In the subgroup consisting of persons without post-COVID syndrome any of the following symptoms:
o Fatigue
o Headache
o Muscle weakness/muscle pain
o Anxiety/depression
o Memory/concentration disorders
o Smell/taste disorders
o Sleep disorders
o Dizziness
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome of the study is the BOLD fMRI signal increase in response to short breath-hold periods, as well as the BOLD signal changes at resting state. The BOLD signal response will be evaluated globally and regionally.
- Secondary Outcome Measures
Name Time Method The correlation of the signal change with the results of clinical examinations will be correlated.