NL-OMON55560尚未招募不适用
Cerebrovascular Reactivity Evaluation Around glioma Treatment using Imaging of Vessels - CREATIV
niversitair Medisch Centrum Utrecht0 个研究点目标入组 10 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 10
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •Suspected to have a high-grade glioma, for which surgical resection (>=20% of
- •enhancing tumour) is planned
- •Eligible for postoperative chemoradiation
- •18 years or older
- •Karnofsky performance status of at least 70
- •Ability to give written informed consent
排除标准
- •Prior cerebral surgery or radiation
- •History of vascular brain disease
- •Non-compliance with prescribed anti-seizure medication
- •CNS haemorrhage of Grade > 1 on baseline MRI scan, unless subsequently
- •documented to have resolved
- •Any known metastatic extracranial or leptomeningeal disease
- •Multifocal disease
- •Clinical signs of increased intracranial pressure even under dexamethasone
- •Unwilling or unable to co-operate with breathing manoeuvres
- •Respiratory or cardiac limitations to breathing at 20 L/min
- •Medical contra-indications to limited hypercapnia (known metabolic acidosis or
- •Standard contraindications for 7T MRI scanning, according to MRI guidelines
- •Postoperative pathology results indicating a lesion other than high-grade
研究者
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