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Clinical Trials/NL-OMON55560
NL-OMON55560
Not yet recruiting
Not Applicable

Cerebrovascular Reactivity Evaluation Around glioma Treatment using Imaging of Vessels - CREATIV

niversitair Medisch Centrum Utrecht0 sites10 target enrollmentTBD

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
brain tumour
Sponsor
niversitair Medisch Centrum Utrecht
Enrollment
10
Status
Not yet recruiting
Last Updated
2 years ago

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
2 years ago
Study Type
Observational invasive

Investigators

Sponsor
niversitair Medisch Centrum Utrecht

Eligibility Criteria

Inclusion Criteria

  • Suspected to have a high\-grade glioma, for which surgical resection (\>\=20% of
  • enhancing tumour) is planned
  • Eligible for postoperative chemoradiation
  • 18 years or older
  • Karnofsky performance status of at least 70
  • Ability to give written informed consent

Exclusion Criteria

  • Prior cerebral surgery or radiation
  • History of vascular brain disease
  • Non\-compliance with prescribed anti\-seizure medication
  • CNS haemorrhage of Grade \> 1 on baseline MRI scan, unless subsequently
  • documented to have resolved
  • Any known metastatic extracranial or leptomeningeal disease
  • Multifocal disease
  • Clinical signs of increased intracranial pressure even under dexamethasone
  • Unwilling or unable to co\-operate with breathing manoeuvres
  • Respiratory or cardiac limitations to breathing at 20 L/min

Outcomes

Primary Outcomes

Not specified

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