Influence of Sevoflurane and Propofol on Maximum Muscular Strength, Speed of Contraction and Relaxation, in Humans: A Pilot Study
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Maximum force at the adductor pollicis
研究概览
简要总结
Many drugs have an influence on neuromuscular transmission. In clinical practice, neuromuscular blocking agents are commonly used, but even in the absence of neuromuscular blocking agents, anesthetic drugs can influence neuromuscular transmission. Especially volatile anesthetic agents have a clinical impact on neuromuscular transmission, they have been shown to prolong and deepen the effect of neuromuscular blocking agents. But even in the absence of neuromuscular blocking agents, volatile anesthetics can impair neuromuscular transmission. One mechanism of action is the desensitization of the acetylcholine receptors by shifting them from a normal to a desensitized state. This effect can weaken neuromuscular transmission by reducing the margin of safety that normally exists at the neuromuscular junction, or can cause an apparent increase in the capacity of neuromuscular blocking agents to block transmission.
In this study, the influence of sevoflurane and propofol on the maximum force, maximum speed of contraction and relaxation will be measured at the adductor pollicis in patients having general anesthesia without the use of neuromuscular blocking agents. Maximum force and speed of contraction and relaxation will be measured before and after anesthesia by either sevoflurane or propofol. Primary outcome is the influence of either anesthetic agent on maximum muscular force and speed of contraction - relaxation, and if this influence is greater for volatile anesthetic agents than for intravenous anesthetic agents.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Any pathology involving neuromuscular transmission
- •Confirmed neuropathy of any origin
- •Expected anesthesia duration < 30 min
- •Renal insufficiency defined as a glomerular filtration rate < 40 mL/min/m2
- •Hepatic insufficiency defined as an increase > 1.5 * normal value of hepatic enzymes
- •Confirmed or suspected pregnancy
- •Language barrier
- •Any patient which will receive unplanned neuromuscular blocking agents during surgery
- •Any history of personal or familial suspected malignant hyperthermia
研究组 & 干预措施
Sevoflurane arm
In this arm, anesthesia will be maintained by sevoflurane.
干预措施: Sevoflurane (Drug)
Propofol arm
In this arm, anesthesia will be maintained by propofol.
干预措施: Propofol (Drug)
结局指标
主要结局
Maximum force at the adductor pollicis
时间窗: 3 hours
Maximum force developed by a voluntary contraction of the adductor pollicis will be measured during isometric contraction. Maximum force developped before and after anesthesia will be compared. The difference in force (Newton) will be measured.
Maximum speed of contraction at the adductor pollicis
时间窗: 3 hours
Maximum speed of contraction developed by a voluntary contraction of the adductor pollicis will be measured during isometric contraction. Maximum speed of contraction developped before and after anesthesia will be compared. The difference in force (Newton/seconds) will be measured.
Maximum speed of relaxation at the adductor pollicis
时间窗: 3 hours
Maximum speed of relaxation developed by a voluntary contraction of the adductor pollicis will be measured during isometric contraction. Maximum speed of relaxation developped before and after anesthesia will be compared. The difference in force (Newton/seconds) will be measured.
次要结局
未报告次要终点
研究者
Denis SCHMARTZ
Anesthesiologists
Université Libre de Bruxelles