The Cohort Study of Pediatric Cataract
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Pediatric Cataract
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
- Enrollment
- 5000
- Locations
- 1
- Primary Endpoint
- Best-corrected visual acuity changes
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
This retrospective-prospective bidirectional cohort study aims to observe ocular parameter changes, different surgical/vision recovery strategies and postoperative adverse effects among young children with cataract. The influence on psychology and cognitive function will be taken into consideration as well.
Detailed Description
Pediatric cataract, one of the leading causes of childhood blindness globally, is complex and of great difficulty in treatment. Pediatric patients with cataract (congenital, traumatic or complicated) are enrolled. In this study, investigators will compare ocular parameter changes, different surgical/vision timing or recovery strategies and adverse effects among young children （age \< 18 yo）before and after cataract surgery. The influence on psychology and cognitive function will be taken into consideration as well. The whole blood samples of participants and parents are collected and retained in our biobank for gene sequencing, hoping to explore the genetic factors in association with pathogenesis. For children received cataract surgery, samples of partial anterior capsular tissue and 1 ml aqueous humor were collected during operation for further analysis. Multimodal artificial intelligence analyses are performed to establish accurate diagnosis/treatment scheme and disease prediction model.
Investigators
Yizhi Liu
Professor
Zhongshan Ophthalmic Center, Sun Yat-sen University
Eligibility Criteria
Inclusion Criteria
- •aged \< 18 yo at the 1st visit unilateral or bilateral cataract agree to participant in this study and sign the informed consent
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Best-corrected visual acuity changes
Time Frame: Baseline and through study completion, an average of 1 year
Best-corrected visual acuity changes are measured by visual acuity charts (Teller/Lea symbol/ETDRS chart) every 1 year at scheduled time
Ocular biological measurements changes
Time Frame: Baseline and through study completion, an average of 1 year
Ocular biological measurements including axial length, corneal keratometry, anterior chamber angle/depth, corneal endothelial cell number and appearance
Incidence changes of postoperative complications
Time Frame: Baseline and through study completion, an average of 1 year
Incidence of postoperative complications, such as glaucoma-related adverse, myopic shift, strabismus and anisometropia and so on
Intraocular pressure changes
Time Frame: Baseline and through study completion, an average of 1 year
Intraocular pressures are measured by NCT machine
Refractive power changes
Time Frame: Baseline and through study completion, an average of 1 year
Refractive power are measured at baseline and every visit at least every 1 year
Secondary Outcomes
- Other factors changes(Baseline and through study completion, an average of 1 year)
- BMI changes(Baseline and through study completion, an average of 1 year)
- Blood pressure changes(Baseline and through study completion, an average of 1 year)
- Stereopsis changes(Baseline and through study completion, an average of 1 year)
- Optical coherence tomography (OCT) changes(Baseline and through study completion, an average of 1 year)